Low-Dose UVA Radiation-Induced Adaptive Response in Cultured Human Dermal Fibroblasts

Table 3

Effects of lethal irradiation on fibroblast apoptosis after UVA preirradiation at different time intervals (𝑥±𝑆%, 𝑛=4).

Group/time	SIG	HDG^a	ARG (J/cm^2)
			7.2	14.4	28.8	57.6	115.2
3 h	2.38±0.47	55.3±6.17	50.2±4.15^b	35.0±4.87^c	39.4±2.21^d	35.2±3.82^e	37.3±3.95^f
6 h	2.68±0.33	54.7±4.11	49.3±4.92^b	42.5±3.93^c	43.9±3.33^d	38.5±2.87^e	41.4±3.02^f
12 h	2.60±0.56	61.9±6.47	55.4±9.26	41.1±3.61^c	45.6±1.05^d	42.0±1.15^e	43.4±4.09^f
24 h	2.70±0.27	59.0±2.81	55.7±6.29	47.8±9.71^c	47.9±4.65^d	45.9±5.45^e	44.8±2.66^f
48 h	2.78±0.25	55.3±5.36	52.9±3.77	56.1±6.00	49.0±6.35^d	48.2±3.34^e	44.1±2.95^f
72 h	2.68±0.33	57.0±3.60	57.5±4.19	54.8±5.19	45.2±4.22^d	49.2±2.44^e	45.9±3.40^f
7 d	2.25±0.45	59.4±5.78	58.1±7.04	56.6±9.56	46.8±7.94^d	48.4±2.44^e	46.6±3.71^f
14 d	2.10±0.46	61.4±3.53	55.1±3.36	60.5±8.16	48.3±6.34^d	47.3±3.82^e	46.8±4.72^f

^a𝑃<0.001, compared with SIG, differences were significant (𝑡=−53.52), ^b𝑃<0.01, compared with HDG, differences in corresponding phase points were significant (𝑡=13.68,16.34), ^c𝑃<0.01, compared with HDG, differences in corresponding phase points were significant (𝑡_3h=18.84, 𝑡_6h=13.00, 𝑡_12h=4.645); ^d𝑃<0.01, compared with HDG, differences in corresponding phase points were significant (𝑡 value in phases, resp., were 7.654, 12.64, 17.69, 21.24, 14.81, 13.21, and 15.84); ^e𝑃<0.01, compared with HDG, differences in corresponding phase points were significant (𝑡 value in phases, resp., were 5.279, 11.63, 7.698, 13.55, 12.85, 4.281, 4.845, and 24.88) ^f𝑃<0.01, compared with HDG, differences in corresponding phase points were significant (𝑡 value in phases, resp., were 6.774, 7.386, 5.047, 24.02, 3.792, 5.146, 9.548, and 16.49).
One-way ANOVA, the proportion of apoptotic fibroblasts showed no difference among the ARG1 (7.2 J/cm²), ARG2 (14.4 J/cm²), and ARG3 (28.8 J/cm²), 𝑃>0.05; 𝑡-test, no difference observed between ARG4 (57.6 J/cm²) and ARG3 (115.2 J/cm²), 𝑃>0.05.