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International Journal of Photoenergy
Volume 2012 (2012), Article ID 829587, 5 pages
Research Article

Low-Level Laser Therapy and Calcitonin in Bone Repair: Densitometric Analysis

1Universidade do Vale do Paraíba (UNIVAP), 12244-000 São José dos Campos, SP, Brazil
2Health Science Faculty, Universidade do Vale do Paraíba (UNIVAP), 12244-000 São José dos Campos, SP, Brazil
3Department of Biosciences and Oral Diagnosis, São José dos Campos Dental School, São Paulo State University (UNESP), 12245-000 São José dos Campos, SP, Brazil
4Biomedical Vibrational Spectroscopy Laboratory, Research and Development Institute (IP&D), Universidade do Vale do Paraíba (UNIVAP), 12244-000 São José dos Campos, SP, Brazil

Received 24 January 2012; Revised 5 April 2012; Accepted 6 April 2012

Academic Editor: Jincai Zhao

Copyright © 2012 Tatiana Pinto Ribeiro et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The aim of this work was to evaluate the association of low-level laser therapy (LLLT, 830 nm) and calcitonin in bone repair considering that bone healing remains a challenge to health professionals. Calcitonin has antiosteoclastic action and LLLT is a treatment that uses low-level lasers or light-emitting diodes to alter cellular function. Both are used to improve bone healing. Densitometry is a clinical noninvasive valuable tool used to evaluate bone mineral density (BMD). Sixty male rats were submitted to bone defect with a trephine bur, randomly divided into four groups of 15 animals each: control (C); synthetic salmon calcitonin (Ca); LLLT (La); LLLT combined with calcitonin (LaCa). Animals from Ca and LaCa received 2 UI/Kg synthetic salmon calcitonin intramuscularly on alternate days after surgery. Animals from groups La and LaCa were treated with infrared LLLT (830 nm, 10 mW, 20 J/cm2, 6 s, contact mode). Five animals from each group were euthanized 7, 14, and 21 days after surgery and bone defects were analyzed by densitometry. Statistical analysis showed a significant difference in BMD values in LaCa group at 7 and 21 days ( 𝑃 = 0 , 0 0 5 ). The results of the densitometric study showed that LLLT (830 nm) combined with calcitonin improved bone repair.