Research Article
Safety Study of Photodynamic Therapy Using Talaporfin Sodium in the Pancreas and Surrounding Tissues in the Syrian Golden Hamster
Table 1
Summary of treatment response of individual hamsters in the safety study.
| | Target organ | Drug dose (mg/kg) | Light dose (J) | Day of cull | Comment |
| | Liver | 1 | 50 | 3 | Macroscopic lesion | | 1 | 50 | 3 | Macroscopic lesion, adhesion to colon | | 1 | 50 | 21 | Small superficial lesion, adhesion to colon | | 1 | 50 | 21 | Small superficial lesion | | 5 | 50 | 3 | Large lesion with adhesion to stomach | | 5 | 50 | 3 | Large lesion with adjacent duodenal injury |
| | Pancreas | 1 | 20 | 3 | Minimal erythema | | 1 | 20 | 3 | No definite effect | | 5 | 20 | 3 | No lesion in pancreas. Adhesions and full thickness gastric lesion | | 1 | 20 | 21 | No lesions | | 1 | 20 | 21 | No lesions | | 1 | 25 | 21 | No lesion in pancreas. Adhesion to liver | | 5 | 20 | 21 | No lesion in pancreas. Scar in stomach | | 5 | 20 | 21 | No lesion in pancreas. Scar in stomach | | 5 | 50 | 12 (>10% weight loss) | Lesion in pancreas, multiple adhesions, ascites, small bowel perforation | | 5 | 50 | 13 (>10% weight loss) | Lesion in pancreas, multiple adhesions, small and large bowel perforation |
| | Duodenum | 2 | 15 | 3 | Sealed perforation, adhesions | | 2 | 20 | 3 | Sealed perforation, adhesions |
| | Spleen | 1 | 20 | 3 | Small lesion, minor bowel adhesion | | 1 | 20 | 3 | Small lesion and subcapsular haematoma |
| | Aorta | 2 | 15 | 3 | No lesions seen | | 2 | 15 | 3 | No lesions seen |
|
|
