Table 2: Identified pharmacogenes in ADHD and asthma.

Gene Variants Asthma ADRB2 p.Arg16Gly, p.Gln27Glu AC9 p.Ile772Met CRHR1 c.122-1310C > A (intronic) TBX21 p.His33Gln LTC4S g.24030224A > C (promotor) CYSLTR1 p.Phe309Phe ALOX5 5′ UTR GSDML c.236-1199G > A (intronic) ADHD DRD4 48 bp allele DAT1 3′ UTR 5-HTT del-1212-1255 (promotor) SNAP-25 3′ UTR COMT p.Val158Met ADRA2A g.31585029G > C

ADRB2: agonists of beta-2 adrenergic receptor; AC9: adenylyl cyclase type 9; CRHR1: corticotropin releasing hormone receptor 1; TBX21: T-box 21; LTC4S: leukotriene C4 synthase; CYSLTR1: cysteinyl leukotriene receptor 1; ALOX5: arachidonate 5-lipoxygenase; GSDML: gasdermin B; DRD4: dopamine receptor 4; DAT1: dopamine transporter 1; 5-HTT: serotonin transporter; SNAP-25: synaptosomal-associated protein; COMT: catechol-O-methyltransferase; ADRA2A: adrenergic alpha2-receptor; UTR: untranslated region.