Table 3: Identified pharmacogenes in childhood ALL. All are affecting the coding regions of the respective genes.

Gene Variants TPMT p.Ala80Pro, p.Ala54Tyr, p.Tyr240Cys GSTT1 Large deletion GSTM1 Large deletion GSTP1 p.Ile105Val MTHFR p.Ala222Val, p.Glu429Ala GGH p.Thr151Ile

TMPT: thiopurine methyltransferase; GST: glutathione-S-transferase family; MTHFR: methylenetetrahydrofolate reductase; GGH: gamma-glutamyl hydrolase.