Clinical Study
Intramural Ganglion Structures in Esophageal Atresia: A Morphologic and Immunohistochemical Study
Table 1
Summary of morphologic and immunohistochemical findings of the esophageal segments in human EA/TEF.
| Tissue | Proximal segment (UEP) | Distal segment (DES) |
| Mucosa | Epithelial hyperplasia | Epithelial hypoplasia | Dysplasia and dystrophy | Dysplasia and dytrophy | Reduction of muscularis mucosae | Absence of muscularis mucosae |
| Submucosa | Hyperplasia of elastic fibers | Hypoplasia of elastic fibers | Infiltration of myofibrilles | Dysplasia and dystrophy | Dysplasia and dystrophy | |
| Circular musculature | Muscular hypoplasia | Muscular hypoplasia | | Fragmentation of the myofibrilles | Disorganization of the myofibrilles |
| Intermuscular collagen and elastic tissues | Connective fibrosis | Connective fibrosis | Endomisial fibrillogenesis | Endomisial fibrillogenesis |
| Myoenteric plexus of auerbach | Reduction of neurocells | Reduction of neurocells | Increase of Schwann’s cells | Increase of Schwann’s cells | Immaturity of neurocells | Immaturity of neurocells |
| Longitudinal musculature | Muscular hypoplasia | Muscular hypoplasia | Fragmentation of the myofibrilles | Disorganization of the myofibrilles |
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