Professional Skills and Competence for Safe and Effective Procedural Sedation in Children: Recommendations Based on a Systematic Review of the Literature

Table 3

Conclusions regarding predictability and controllability of nontitratbale drugs intended for PS.

Nr	Conclusion	Quality Level
(1)	For a PS with medicines that are difficult to titrate and/or long-acting (e.g., chloral hydrate, midazolam, barbiturates, opiates or combinations), the eventual depth of sedation, effectiveness and duration of the sedation and timing of adverse events cannot reliably be predicted. Therefore, possible adverse effects of any possible sedation depth should always be anticipated in terms of recognition and treatment.	Level 2
	(B) Hoffman et al. 2002 [13], Newman et al. 2003 [34], Malviya et al. 2004 [63], Motas et al. 2004 [21]