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International Journal of Pediatrics
Volume 2012 (2012), Article ID 541892, 5 pages
http://dx.doi.org/10.1155/2012/541892
Clinical Study

Prenatal Characteristics of Infants with a Neuronal Migration Disorder: A National-Based Study

1Department of Women's and Children's Health, Uppsala University, Akademiska Sjukhuset, 751 85 Uppsala, Sweden
2Department of Paediatrics, Östersund County Hospital, 831 83 Östersund, Sweden
3Uppsala University Children's Hospital, 751 85 Uppsala, Sweden
4Department of Medicine, Centre for Pharmacoepidemiology, Karolinska Institutet, 171 76 Stockholm, Sweden

Received 9 November 2011; Revised 1 February 2012; Accepted 3 February 2012

Academic Editor: Sheffali Gulati

Copyright © 2012 Estelle Naumburg et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The development of the central nervous system is complex and includes dorsal and ventral induction, neuronal proliferation, and neuronal migration, organization, and myelination. Migration occurs in humans in early fetal life. Pathogenesis of malformations of the central nervous system includes both genetic and environmental factors. Few epidemiological studies have addressed the impact of prenatal exposures. All infants born alive and included in the Swedish Medical Birth Register 1980–1999 were included in the study. By linkage to the Patient Register, 820 children with a diagnosis related to a neuronal migration abnormality were identified. Through copies of referrals for computer tomography or magnetic resonance imaging of the brain, the diagnosis was confirmed in 17 children. Median age of the mothers was 29 years. At the start of pregnancy, four out of 17 women smoked. Almost half of the women had a body mass index that is low or in the lower range of average. All infants were born at term with normal birth weights. Thirteen infants had one or more concomitant diseases or malformations. Two infants were born with rubella syndrome. The impact of low maternal body mass index and congenital infections on neuronal migration disorders in infants should be addressed in future studies.