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International Journal of Pediatrics
Volume 2012 (2012), Article ID 906570, 5 pages
http://dx.doi.org/10.1155/2012/906570
Review Article

Promoting Appropriate Use of Drugs in Children

General Pediatric Division, Dr. Yewale's Multispeciality Hospital for Children, Vashi, Navi Mumbai 400703, India

Received 1 July 2011; Revised 4 January 2012; Accepted 17 February 2012

Academic Editor: Nithya J. Gogtay

Copyright © 2012 Vijay N. Yewale and Dhanya Dharmapalan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Promotion of appropriate and safe drugs in children is the need of the hour globally. Pediatric population by itself is a spectrum of different physiologies with significant variation in pharmacodynamics and pharmacokinetics. Unfortunately, 50–90% of drugs used in children today have never been actually studied in this population, and the results of drug studies done in adults are often extrapolated for use in children. Many medicines in pediatrics are off label or unlicensed. There is a spurt in drug resistance due to the overzealous prescription of antimicrobials not indicated, such as, using inadequate dosage or duration of drug regime leading to partially treated infections, using the wrong antimicrobial due to ignorance of causative organism, and finally using indigenous, irrational combinations. Availability of properly labeled and safe pediatric formulations, regular audit by pharmacists, judicious prescriptions, proper counseling about drug administration, surveillance of adverse effects, and pediatric drug trials can be the best possible interventions to offer appropriate medicines to children and thereby save millions of lives.