Table 2: Identified pharmacogenes in ADHD and asthma.

GeneVariants

AsthmaADRB2p.Arg16Gly, p.Gln27Glu
AC9p.Ile772Met
CRHR1c.122-1310C > A (intronic)
TBX21p.His33Gln
LTC4Sg.24030224A > C (promotor)
CYSLTR1p.Phe309Phe
ALOX55′ UTR
GSDMLc.236-1199G > A (intronic)

ADHDDRD448 bp allele
DAT13′ UTR
5-HTTdel-1212-1255 (promotor)
SNAP-253′ UTR
COMTp.Val158Met
ADRA2Ag.31585029G > C

ADRB2: agonists of beta-2 adrenergic receptor; AC9: adenylyl cyclase type 9; CRHR1: corticotropin releasing hormone receptor 1; TBX21: T-box 21; LTC4S: leukotriene C4 synthase; CYSLTR1: cysteinyl leukotriene receptor 1; ALOX5: arachidonate 5-lipoxygenase; GSDML: gasdermin B; DRD4: dopamine receptor 4; DAT1: dopamine transporter 1; 5-HTT: serotonin transporter; SNAP-25: synaptosomal-associated protein; COMT: catechol-O-methyltransferase; ADRA2A: adrenergic alpha2-receptor; UTR: untranslated region.