Pharmacogenomics in Children: Advantages and Challenges of Next Generation Sequencing Applications

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Gene</td><td align="center">Variants</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">TPMT</td><td align="center">p.Ala80Pro, p.Ala54Tyr, p.Tyr240Cys</td></tr><tr><td align="left">GSTT1</td><td align="center">Large deletion</td></tr><tr><td align="left">GSTM1</td><td align="center">Large deletion</td></tr><tr><td align="left">GSTP1</td><td align="center">p.Ile105Val</td></tr><tr><td align="left">MTHFR</td><td align="center">p.Ala222Val, p.Glu429Ala</td></tr><tr><td align="left">GGH</td><td align="center">p.Thr151Ile</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td>
								TMPT: thiopurine methyltransferase; GST: glutathione-S-transferase family; MTHFR: methylenetetrahydrofolate reductase; GGH: gamma-glutamyl hydrolase. <br/></td></tr></table>

Identified pharmacogenes in childhood ALL. All are affecting the coding regions of the respective genes. 

International Journal of Pediatrics

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Table 3

Table 3: Pharmacogenomics in Children: Advantages and Challenges of Next Generation Sequencing Applications 