Table 3: Identified pharmacogenes in childhood ALL. All are affecting the coding regions of the respective genes.

GeneVariants

TPMTp.Ala80Pro, p.Ala54Tyr, p.Tyr240Cys
GSTT1Large deletion
GSTM1Large deletion
GSTP1p.Ile105Val
MTHFRp.Ala222Val, p.Glu429Ala
GGHp.Thr151Ile

TMPT: thiopurine methyltransferase; GST: glutathione-S-transferase family; MTHFR: methylenetetrahydrofolate reductase; GGH: gamma-glutamyl hydrolase.