Clinical Study
Doxapram Use for Apnoea of Prematurity in Neonatal Intensive Care
Table 1
Patient characteristics of included premature neonates who received doxapram (Total
).
| | | Overall () | Successfully treated patients () | Unsuccessfully treated patients () | | | | Percentage | Median (IQR) | Percentage | Median (IQR) | Percentage | Median (IQR) |
| | Birth weight (gram) | | 937 (267) | | 980 (267) | | 915 (332) | 0.21 | | Gestational age (weeks) | | 27 (1.7) | | 27 (2.2) | | 27 (2.6) | 0.21 | | Apgar score | | | | | | | | | 1 min | | 5 (4) | | 6 (4) | | 5 (4) | 0.09 | | 5 min | | 8 (2) | | 8 (2) | | 8 (2) | 0.08 | | Mode of delivery: | | | | | | | | | Vaginal | 66.7% | | 68.0% | | 61.1% | | | | Caesarean section | 33.3% | | 32.0% | | 38.9% | | | | Maternal corticosteroids | | | | | | | | | Adequate* | 42.1% | | 43.2% | | 37.1% | | | | Inadequate | 31.6% | | 32.4% | | 31.4% | | | | Centre1/centre 2 | 68.9%/31.1% | | 69.2%/65.8% | | 30.8%/34.2% | | | | Gender (m/f) | 50%/50% | | 49.4%/50.6% | | 54.1/45.9% | | | | Twin | 35.2% | | 41.7% | | 24.3% | | | | Primary ventilation | 37.7% | | 27.8% | | 56.8% | | | | Ventilation before doxapram | 80.7% | | 76.3% | | 86.5% | | | | Surfactant therapy | 74.6% | | 67.1% | | 86.1% | | | | Caffeine | 98.3% | | 98.7% | | 97.3% | | | | Theophylline | 32.0% | | 31.6% | | 29.7% | | |
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Maternal corticosteroid therapy was judged adequate if two doses were given more than 24 hours before birth.
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