Flow Cytometry in the Detection of Neonatal Sepsis

Table 1

EONS: early-onset neonatal sepsis; LONS: late-onset neonatal sepsis; VLBW: very low birth weight neonates; PPV: positive predictive value; NPV: negative predictive value; wga: weeks of gestational age.

		Sensitivity	Specificity	PPV	NPV	Patients’ characteristics/comments	Reference
EONS	CD64	96	81	71	97	𝑛=453, term	[21]
		100	86		100	𝑛=749, VLBW, LBW, term	[22]
	CD11b	100	100			𝑛=39, 29–40 wga	[23]
	CRP	81	56	48	85	𝑛=453, term	[21]
	CRP + CD64	97	71	63	98		[21]
LONS	CD64	95	88	80	97	𝑛=127, VLBW	[18]
		75			96	𝑛=749, VLBW, LBW, term	[22]
		91	83	83	91	𝑛=37; >30 wga	[17]
		70	62	59	73	𝑛=163, preterm	[24]
	CD11b	70	72	50	86	𝑛=127, VLBW	[18]
		75	100	100	86	𝑛=65, 27–38 wga	[25]
		86	100	100	68	𝑛=51, term	[26]
	IL-6	78	92	81	91	𝑛=127, VLBW	[18]
	CRP	9	83	33	50	𝑛=37; >30 wga	[17]
		65	99	96	87	𝑛=127, VLBW	[18]
	CRP + CD64	100	66			𝑛=37; >30 wga	[17]
		100	80	90	100	𝑛=127, VLBW	[18]
	CRP + CD11b	99			99	𝑛=65, 27–38 wga	[25]