- About this Journal ·
- Abstracting and Indexing ·
- Advance Access ·
- Aims and Scope ·
- Article Processing Charges ·
- Articles in Press ·
- Author Guidelines ·
- Bibliographic Information ·
- Citations to this Journal ·
- Contact Information ·
- Editorial Board ·
- Editorial Workflow ·
- Free eTOC Alerts ·
- Publication Ethics ·
- Reviewers Acknowledgment ·
- Submit a Manuscript ·
- Subscription Information ·
- Table of Contents
International Journal of Pediatrics
Volume 2013 (2013), Article ID 768784, 6 pages
Microcirculatory Changes in Term Newborns with Suspected Infection: An Observational Prospective Study
1Division of Neonatology Perinatal Center, Department of Gynecology and Obstetrics, Ludwig-Maximilians University Munich, 80337 Munich, Germany
2Division of Neonatology, University Children’s Hospital, Ludwig-Maximilians University Munich, 80337 Munich, Germany
Received 21 October 2012; Revised 17 December 2012; Accepted 18 December 2012
Academic Editor: Mohan Pammi
Copyright © 2013 Irene Alba-Alejandre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- S. Schrag and A. Schuchat, “Prevention of neonatal sepsis,” Clinics in Perinatology, vol. 32, no. 3, pp. 601–615, 2005.
- A. Amaral, S. M. Opal, and J. L. Vincent, “Coagulation in sepsis,” Intensive Care Medicine, vol. 30, no. 6, pp. 1032–1040, 2004.
- M. A. Short, “Linking the sepsis triad of inflammation, coagulation, and suppressed fibrinolysis to infants,” Advances in Neonatal Care, vol. 4, no. 5, pp. 258–273, 2004.
- T. Sordia, J. Tatarishvili, and G. Mchedlishvili, “Hemorheological disorders in the microcirculation during septic shock in rats,” Clinical Hemorheology and Microcirculation, vol. 35, no. 1-2, pp. 223–226, 2006.
- M. Chierego, C. Verdant, and D. De Backer, “Microcirculatory alterations in critically ill patients,” Minerva Anestesiologica, vol. 72, no. 4, pp. 199–205, 2006.
- D. De Backer and M. J. Dubois, “Assessment of the microcirculatory flow in patients in the intensive care unit,” Current Opinion in Critical Care, vol. 7, no. 3, pp. 200–203, 2001.
- D. De Backer, J. Creteur, J. C. Preiser, M. J. Dubois, and J. L. Vincent, “Microvascular blood flow is altered in patients with sepsis,” American Journal of Respiratory and Critical Care Medicine, vol. 166, no. 1, pp. 98–104, 2002.
- C. Ince, “The microcirculation is the motor of sepsis,” Critical Care, vol. 9, supplement 4, pp. S13–S19, 2005.
- S. Trzeciak and E. P. Rivers, “Clinical manifestations of disordered microcirculatory perfusion in severe sepsis,” Critical Care, vol. 9, supplement 4, pp. S20–S26, 2005.
- J. L. Vincent and D. De Backer, “Microvascular dysfunction as a cause of organ dysfunction in severe sepsis,” Critical Care, vol. 9, supplement 4, pp. S9–S12, 2005.
- W. Groner, J. W. Winkelman, A. G. Harris et al., “Orthogonal polarization spectral imaging: a new method for study of the microcirculation,” Nature Medicine, vol. 5, no. 10, pp. 1209–1212, 1999.
- A. G. Harris, I. Sinitsina, and K. Messmer, “Validation of OPS imaging for microvascular measurements during isovolumic hemodilution and low hematocrits,” American Journal of Physiology, vol. 282, no. 4, pp. H1502–H1509, 2002.
- S. Langer, A. G. Harris, P. Biberthaler, E. von Dobschuetz, and K. Messmer, “Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation,” Transplantation, vol. 71, no. 9, pp. 1249–1256, 2001.
- K. R. Mathura, K. C. Vollebregt, K. Boer, J. C. De Graaff, D. T. Ubbink, and C. Ince, “Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation,” Journal of Applied Physiology, vol. 91, no. 1, pp. 74–78, 2001.
- A. P. C. Top, M. van Dijk, J. E. van Velzen, C. Ince, and D. Tibboel, “Functional capillary density decreases after the first week of life in term neonates,” Neonatology, vol. 99, no. 1, pp. 73–77, 2011.
- O. Genzel-Boroviczény, J. Strötgen, A. G. Harris, K. Messmer, and F. Christ, “Orthogonal polarization spectral imaging (OPS): a novel method to measure the microcirculation in term and preterm infants transcutaneously,” Pediatric Research, vol. 51, no. 3, pp. 386–391, 2002.
- O. Genzel-Boroviczény, F. Christ, and V. Glas, “Blood transfusion increases functional capillary density in the skin of anemic preterm infants,” Pediatric Research, vol. 56, no. 5, pp. 751–755, 2004.
- J. Kroth, K. Weidlich, S. Hiedl, C. Nussbaum, F. Christ, and O. Genzel-Boroviczény, “Functional vessel density in the first month of life in preterm neonates,” Pediatric Research, vol. 64, no. 5, pp. 567–571, 2008.
- K. Weidlich, J. Kroth, C. Nussbaum et al., “Changes in microcirculation as early markers for infection in preterm infants-an observational prospective study,” Pediatric Research, vol. 66, no. 4, pp. 461–465, 2009.
- E. C. Boerma, K. R. Mathura, P. H. van der Voort, P. E. Spronk, and C. Ince, “Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study,” Critical Care, vol. 9, no. 6, pp. R601–R606, 2005.
- J. Dembinski, D. Behrendt, J. Reinsberg, and P. Bartmann, “Endotoxin-stimulated production of IL-6 and IL-8 is increased in short-term cultures of whole blood from healthy term neonates,” Cytokine, vol. 18, no. 2, pp. 116–119, 2002.
- A. Hebra, P. Strange, J. M. Egbert, M. Ali, A. Mullinax, and E. Buchanan, “Intracellular cytokine production by fetal and adult monocytes,” Journal of Pediatric Surgery, vol. 36, no. 9, pp. 1321–1326, 2001.
- M. A. Mohamed, S. Cunningham-Rundles, C. R. Dean, T. A. Hammad, and M. Nesin, “Levels of pro-inflammatory cytokines produced from cord blood in-vitro are pathogen dependent and increased in comparison to adult controls,” Cytokine, vol. 39, no. 3, pp. 171–177, 2007.
- K. N. Haque, “Definitions of bloodstream infection in the newborn,” Pediatric Critical Care Medicine, vol. 6, no. 3, supplement, pp. S45–S49, 2005.
- C. Chiesa, G. Pellegrini, A. Panero et al., “C-reactive protein, interleukin-6, and procalcitonin in the immediate postnatal period: influence of illness severity, risk status, antenatal and perinatal complications, and infection,” Clinical Chemistry, vol. 49, no. 1, pp. 60–68, 2003.
- J. E. Fischer, “Physicians' ability to diagnose sepsis in newborns and critically ill children,” Pediatric Critical Care Medicine, vol. 6, no. 3, supplement, pp. S120–S125, 2005.
- W. E. Benitz, M. Y. Han, A. Madan, and P. Ramachandra, “Serial serum C-reactive protein levels in the diagnosis of neonatal infection,” Pediatrics, vol. 102, no. 4, p. E41, 1998.
- H. Døllner, L. Vatten, and R. Austgulen, “Early diagnostic markers for neonatal sepsis: comparing C-reactive protein, interleukin-6, soluble tumour necrosis factor receptors and soluble adhesion molecules,” Journal of Clinical Epidemiology, vol. 54, no. 12, pp. 1251–1257, 2001.
- G. Laborada, M. Rego, A. Jain et al., “Diagnostic value of cytokines and C-reactive protein in the first 24 hours of neonatal sepsis,” American Journal of Perinatology, vol. 20, no. 8, pp. 491–501, 2003.
- P. C. Ng, “Diagnostic markers of infection in neonates,” Archives of Disease in Childhood, vol. 89, no. 3, pp. F229–F235, 2004.
- M. J. Stark, V. L. Clifton, and I. M. R. Wright, “Neonates born to mothers with preeclampsia exhibit sex-specific alterations in microvascular function,” Pediatric Research, vol. 65, no. 3, pp. 291–295, 2009.