Early Blood Gas Predictors of Bronchopulmonary Dysplasia in Extremely Low Gestational Age Newborns
Table 4
Odds ratios (and 95% confidence intervals of the association between blood gas abnormalities (defined as the extreme quartile for gestational age on at least two of the first three days) and BPD. The referent group consists of all infants who did not have severe or very severe BPD. The sets of tables differ in the inclusion/exclusion of one variable in the multivariable models. In the top set, days of ventilation during the NICU stay (<7, 7–13, ≥14) are not included in the model, while this variable is included in the bottom set.
(a) Without a variable for days of ventilation during the first 2 weeks (<7, 7–13, and ≥14)
BPD
Blood gas abnormalities
Low PO2
High PO2
Low PCO2
High PCO2
Severe
1.5 (1.02, 2.3)
0.9 (0.6, 1.4)
0.6 (0.4, 0.96)
1.3 (0.9, 2.0)
Very severe
2.5 (1.3, 5.0)
0.7 (0.3, 1.5)
0.5 (0.3, 1.03)
2.5 (1.2, 5.0)
(b) With a variable for days of ventilation during the first 2 weeks (<7, 7–13, ≥14)
BPD
Blood gas abnormalities
Low PO2
High PO2
Low PCO2
High PCO2
Severe
1.2 (0.8, 1.9)
0.9 (0.6, 1.5)
0.6 (0.4, 0.96)
0.9 (0.6, 1.5)
Very severe
1.7 (0.8, 3.5)
0.8 (0.3, 1.8)
0.4 (0.2, 0.9)
1.9 (0.9, 4.2)
All models are adjusted for conception assistance, maternal fever during pregnancy, birth weight -score <−1, recovery of a Mycoplasma from the placenta, and SNAPPE ≥45. These models also include a hospital group/cluster term to account for the possibility that infants born at a particular hospital are more like each other than infants born at other hospitals.
