Effects of Whole Body Therapeutic Hypothermia on Gastrointestinal Morbidity and Feeding Tolerance in Infants with Hypoxic Ischemic Encephalopathy
Table 2
Primary and secondary outcome variables for strict criteria group.
Variable
WBTH ()
Non-WBTH ()
value
Primary outcomes (mean ± SD)
DOL enteral feeds started
0.12
DOL full enteral feeds reached
0.02*
DOL full oral feeds reached
0.01*
Secondary outcomes (%)
Never started enteral feeds
5.6
28.1
0.02*
Never reached full enteral feeds
5.6
37.5
0.002*
Never reached full oral feeds
19.4
56.3
0.002*
Death
5.7
32.3
0.009*
GT
5.6
15.6
0.24
Combined death and GT
11.1
46.9
0.001*
Discharged with gavage feeds
5.6
9.4
0.66
Combined death and discharged with gavage feeds
11.1
43.8
0.005*
NEC+
0
9.4
0.1
ECMO
8.3
0
0.24
Elevated liver enzymes†
63.9
63
0.94
Elevated coagulation parameters∞
100
91.3
0.15
Days to hospital discharge or death
1
*Significance defined by P < 0.05.
+Grossly bloody stool (Bell’s stage IIA or greater). †Aspartate aminotransferase level >200 IU and alanine aminotransferase level >100 IU. ∞Prothrombin time >15.6 seconds and partial thromboplastin time >41.5 seconds.
