Clinical Study
Neonatal Thrombocytopenia after Perinatal Asphyxia Treated with Hypothermia: A Retrospective Case Control Study
Box 1
Selection criteria for therapeutic hypothermia at the Leiden University Medical Center.
(i) Gestational age at birth ≥36 weeks | (ii) AND perinatal asphyxia defined as: | Apgar score at 5 minutes ≤5 OR | respiratory failure requiring resuscitation measures during at least 10 minutes after birth OR | arterial pH <7.0 and base excess ≤−16 mmol/L in either arterial umbilical cord blood | sample/arterial blood gas within one hour after birth OR | lactate >10 mmol/L in either arterial umbilical cord blood sample or arterial blood gas | within one hour after birth | (iii) AND Encephalopathy with: | Thompson score >7 between 1 and 3 hours after birth OR | abnormal background pattern on aEEG | (iv) AND Start time of hypothermia as soon as possible, at least within 6 hours after birth. |
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