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International Journal of Pediatrics
Volume 2014 (2014), Article ID 937212, 5 pages
http://dx.doi.org/10.1155/2014/937212
Clinical Study

The Effect of Probiotics on Childhood Constipation: A Randomized Controlled Double Blind Clinical Trial

1Department of Pediatrics, Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
2Zanjan University of Medical Sciences, Zanjan, Iran
3Department of Pediatrics, Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran
4Department of Epidemiology, Zanjan University of Medical Sciences, Zanjan, Iran
5Department of Pediatrics, Zanjan University of Medical Sciences, Zanjan, Iran

Received 14 December 2013; Revised 19 February 2014; Accepted 25 February 2014; Published 9 April 2014

Academic Editor: Joel R. Rosh

Copyright © 2014 M. Sadeghzadeh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Inconsistent data exist about the role of probiotics in the treatment of constipated children. The aim of this study was to investigate the effectiveness of probiotics in childhood constipation. Materials and Methods. In this placebo controlled trial, fifty-six children aged 4–12 years with constipation received randomly lactulose plus Protexin or lactulose plus placebo daily for four weeks. Stool frequency and consistency, abdominal pain, fecal incontinence, and weight gain were studied at the beginning, after the first week, and at the end of the 4th week in both groups. Results. Forty-eight patients completed the study. At the end of the fourth week, the frequency and consistency of defecation improved significantly ( and , resp.). At the end of the first week, fecal incontinence and abdominal pain improved significantly in intervention group ( and , resp.) but, at the end of the fourth week, this difference was not significant ( and , resp.). A significant weight gain was observed at the end of the 1st week in the treatment group. Conclusion. This study showed that probiotics had a positive role in increasing the frequency and improving the consistency at the end of 4th week.