Research Article
Morbidity and Mortality in Preterm Infants following Antacid Use: A Retrospective Audit
Table 3
Frequency and odds ratios of neonatal outcomes in group exposed to ranitidine/omeprazole.
| Outcome | Not exposed to ranitidine/omeprazole () | Exposed to ranitidine/omeprazole () | Odds ratio (95% CI) | value |
| Total late onset sepsis (culture positive + clinical sepsis) | 33.1% (98) | 26.6% (17) | 0.73 (0.4–1.34) | 0.384 | Culture positive late onset sepsis | 24% (71) | 14.1% (9) | 0.52 (0.24–1.1) | 0.117 | NEC (all stages) | 8.4% (25) | 3.1% (2) | 0.35 (0.08–1.5) | 0.192 | NEC Bell stage ≥2 | 3.7% (11) | 1.6% (1) | 0.4 (0.05–3.2) | 0.7 | Mortality | 8.4% (25) | 3.1% (2) | 0.35 (0.08–1.5) | 0.19 | | 0.7% (2) | 3.1% (2) | 4.7 (0.65–34.3) | 0.147 | | 1.7% (5) | 3.1% (2) | 1.9 (0.36–9.9) | 0.613 |
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Values may be underestimates due to underreporting and poor documentation in NICU.
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