Effect of Ghrelin on Glucose-Insulin Homeostasis: Therapeutic Implications

Table 3

Results obtained with cellular cultures and pancreatic perfusion that contribute to data about ghrelin role on glucose and insulin metabolism.

Cellular type/Perfusion	Treatment	Dose	Insulin release	Glucose output	Reference
Islets from normal rats	AG + glucose versus glucose	10^-12M AG + 2.8 mM glucose	Not change		[54]
	AG + glucose versus glucose	10^-12M AG + 8.3 mM glucose	Enhanced
Islets from normal rats	AG + glucose versus glucose	10^-8M AG + 2.8 mM glucose	Not change		[58]
	AG + glucose versus glucose	10^-8M AG + 8.3 mM glucose	Diminished
Islets from normal rats	AG + glucose versus glucose	10 nM AG + 20 mM glucose	Diminished		[92]
	UAG + glucose versus glucose	1 𝜇M + 20 mM glucose	Not change
	AG + glucose + YIL-781 versus glucose	10 nM AG + 20 mM glucose + 1 𝜇M YIL-781	Not change
	Glucose + YIL-781 versus glucose	20 mM glucose + 1 𝜇M YIL-781	Not change
Islets from normal rats	GHRP-6 versus placebo	1 𝜇M GHRP-6	Enhanced		[58]
	SPA versus placebo	1 𝜇M SPA	Enhanced
Ghrelin KO mouse islets	Glucose ghrelin KO versus glucose wildtype	8.3 mM and 16.7 mM glucose	Enhanced		[91]
Min 6 cells	AG + glucose versus glucose	1–10 nM AG + 22.2 mM glucose	Diminished		[93]
Hepatocytes from pigs	AG versus placebo	100 nM AG		Enhanced	[96]
	UAG versus placebo	100 nM UAG		Diminished
	UAG + AG versus AG	100 nM AG + 100 nM UAG		Diminished
Pancreas of rat perfused in situ	Ghrelin + glucose versus glucose	10 nM ghrelin + 5.5 mM glucose	Not change		[90]
	Ghrelin + glucose versus glucose	10 nM ghrelin + 9 mM glucose	Diminished
Pancreas of rat perfused in vitro	Ghrelin + glucose versus glucose	10 nM ghrelin + 8,3 mM glucose	Diminished		[91]
	GHRP-6 + glucose versus glucose	1 𝜇M GHRP-6 + 8.3 mM glucose	Enhanced
	UAG + glucose versus glucose	10 nmol/l UAG + 8.3 mM glucose	Not change