|
Null mice | Treatment | Dose | Food before/during experiment | Measurement blood samples | Plasma glucose levels | Plasma insulin levels | Reference |
|
Ghrelin | KO versus wildtype | | SCD 4–20 weeks old | Endpoint | Not change | Not change | [35] |
|
Ghrelin | KO versus wildtype | | SCD 4–10 weeks of age | Endpoint | Not change | Not change | [103] |
|
Ghrelin | IP-GTT, KO versus wildtype | 2 g glucose/kg | SCD, fasted | Time course-2 hours | Diminished | Enhanced |
[91] |
KO versus wildtype | | SCD, fed | Endpoint | Endpoint | Not change |
KO HDF versus KO SCD | | HFD 8–12 weeks old | Endpoint | Not change | Enhanced |
IP-GTT, KO HFD versus KO SCD | 2 g glucose/kg | HFD 8–12 weeks old | Time course-2 hours | Not change | Enhanced |
|
Ghrelin | IP-GTT, KO versus wildtype | 2.5 g glucose/kg | SCD 8-week old | Time course-2 hours | Diminished | Enhanced | [36] |
|
Ghrelin | KO versus wildtype | | SCD, 6 hours fast | Endpoint | Not change | Not change | [37] |
|
| AG versus saline | 2.5 g glucose/kg + 1 IP injection of 150 nmol AG/kg | SCD 8-week old, 18 h fast | Time course-2 hours | Enhanced | Diminished |
[36] |
| ITT, KO versus wildtype | 0.75 U/kg | SCD 8-week old, 8h fast | Time course-2.5 hours | Diminished | |
Ghrelin | Hyperinsulinemic-euglycemic clamp, KO versus wildtype | | SCD 8-week old | | GIR enhanced during clamp | |
| KO versus wildtype | | SCD 12-week old | Endpoint | Not change | Not change |
| KO.ob/ob versus wildtype.ob/ob | | SCD 12-week old | Endpoint | Diminished | Enhanced |
| KO.ob/ob versus wildtype.ob/ob | | SCD 12-week old, 24 hours fast | Endpoint | Diminished | Not change |
|
Ghrelin | IP-GTT, KO versus wildtype | 2 g glucose/kg | SCD, 6 hours fast | Time course-2 hours | Not change | Not change |
[37] |
ITT, KO versus wildtype | 1 U/kg | SCD, 6 hours fast | Time course-2 hours | Not change | Not change |
|
Ghrelin | O-GTT, KO DIO versus wildtype DIO | 1 g glucose/kg | HFD 8–23 weeks old, 16 hours fast | Time course-2 hours | Not change | Diminished | [33] |
|
Ghrelin | KO versus wildtype | | 10-week SCD + 40 days on 50% caloric restriction with SCD | Time course every 2 days | 2–16 day diminished | | [34] |
|
| KO DIO versus wildtype DIO | | HFD 8–23 weeks old | Endpoint | diminished | Diminished | |
| IPGTT, KO DIO versus wildtype DIO | 1 g glucose/kg | HFD 8–23 weeks old, 16 hours fasted | Time course-2 hours | Not change | Diminished |
[33] |
|
Ghrelin | Hyperinsulinemic-euglycemic clamp, KO DIO versus wildtype DIO | 10 mU insulin/kg + constant infused insulin 5 mU/kg/min + infused 20% glucose | HFD 8–23 weeks old, 16 hours fast | Time course-1.5 hours | GIR enhanced | |
| Hyperglycemic clamp KO DIO versus wildtype DIO | 20% glucose at rates that stabilized blood glucose at 300 mg/dl | HFD 8–23 weeks old, 16 hours fasted | Time course-1.5 hours | | Diminished | |
| KO versus wildtype | | 24-week SCD | Endpoint | Not change | Not change | |
| KO versus wildtype | | 24-week SCD/18 h-fasting | Endpoint | Diminished | Diminished | |
GHSR | KO versus wildtype | | 10-week SCD + 40 days on 50% caloric restriction with SCD | Time course every two days | 2–28 day diminished | | [34] |
| KO versus wildtype | | 14-week SCD +10-week HF + 18 h-fasting | Endpoint | Not change | Not change | |
| KO versus wildtype | | 14-week SCD +10-week HF | Endpoint | Not change | Not change | |
|
| IP-GTT KO versus wildtype | 2 g glucose/kg | SCD, 6 hours-fasting | Time course 2 hours | Not change | Not change |
[37] |
GHSR | ITT KO versus wildtype | 1 U/kg | SCD, 6 hours-fasting | Time course 2 hours | Not change | Not change |
| KO versus wildtype | | SCD, 6 hours-fasting | Endpoint | Not change | Not change |
|
GHSR | KO versus wildtype | | SCD 4–19 weeks old | Endpoint | Diminished | Diminished | [104] |
|
GHSR | KO versus wildtype | | SCD 8-week old | Endpoint | Diminished | Diminished | [105] |
|
Ghrelin + GHSR | IP-GTT dKO versus wildtype | 2 g glucose/kg | SCD, 6 hours-fasting | Time course-2 hours | Not change | Not change |
[37] |
dKO versus wildtype | | SCD, 6 hours-fasting | Endpoint | Not change | Not change |
ITT dKO versus wildtype | 1 U/kg | SCD, 6 hours-fasting | Time course-2 hours | Not change | Not change |
|