|
| Author | Subjects | Study design | Ghrelin type | Effective dose | Methods | Results |
|
| Levin F., [39] | Healthy volunteers (5M, 3F) | Randomized, double-blind, placebo-controlled, crossover | Ghrelin | 10 pmol/Kg/min for 180 min after meal | Assessment of solid GE by scintigraphy | Ghrelin accelerated the rate of GE |
|
| Tack J., [35] | Healthy fasting volunteers (4F, 5M) | Cross-sectional | Ghrelin (Clinalfa, Switzerland) | 40 g IV infusion over 30 min given 20 min after the end of phase III of MMCs | Assessment of antroduodenal motility and gastric tone by manometry
and barostat | Ghrelin induced premature phase III contractions and increased the tone of the proximal stomach |
|
| Cremonini F., [37] | Healthy volunteers: obese (5M, 20F) and | Randomized, parallel-group, one dose, double-blind, placebo-controlled | Ghrelin (Clinalfa, Switzerland) | 0.33 g/Kg IV given 10 minutes after IV injection of Tc-pertechnetate | Assessment of gastric volume and emptying by SPECT | Ghrelin marginally decreased fasting gastric volumes, but not GE or symptoms |
| normal weight (13F) | Assessment of symptoms by VAS |
|
| Bisschops R., [36] | Healthy volunteers () | No information | () Ghrelin | 40 g IV infusion over 30 min given 20 min after the end of phase III of MMCs | Assessment of antroduodenal pressures by manometry and gastric tone by barostat | () Ghrelin induced phase III contractions of gastric origin; those were of increased amplitude and duration. |
| () GHRP-6(Clinalfa, Switzerland) | () Ghrelin increased proximal gastric tone |
|
| Ang D., [38] | Healthy volunteers (4M, 6F) | Randomized, placebo-controlled, double-blind, cross over | Ghrelin | 40 g IV infusion over 30 min given10 min before meal | Assessment of gastric accommodation by barostat | () Ghrelin inhibited gastric accommodation and decreased postprandial gastric volumes |
| () Ghrelin had no effects on postprandial symptoms |
|
