Brain Activation by Peptide Pro-Leu-Gly-NH_𝟐 (MIF-1)

Table 1

Relative numbers of c-Fos (+) cells after MIF-1 treatment.

Structure abbreviation	Figure 1 diagram	Structure	Saline	icv	iv
cg1	(1)(a)–(c)	Cingulate cortex, area1	+^a	+^a	+++++^c
cg2	(2)(a)–(c)	Cingulate cortex, area2	+^a	+^a	++++^d
IL	(1)(a)–(c)	Infralimbic cortex	+	o	++^b
DEn	(1)(a)–(c)	Dorsal endopiriform cortex	+++^b	++	+++^d
CPu	(1)(a)–(c)	Caudate, putamen	+	o	++^d
AcbC	(1)(a)–(c)	Accumbens nucleus, core	+	+	+++++^d
Pir	(3)(a)–(c)	Piriform cortex	++^b	++^b	+++^b
PaDC	(5)(a)–(c)	Paraventricular hypothalamic nucleus, dorsal cap	+++	+++	+++++^d
PaLM	(5)(a)–(c)	Paraventricular hypothalamic nucleus, lateral magnocellular	+++	+++	+++++^d
PV	(6)(a)–(c)	Paraventricular thalamic nu	+++	+	+++++^d
PCom	(7)(a)–(c)	Nucleus of posterior commissure	++^b	+	++^b
MCPC	(7)(a)–(c)	Magnocellular nucleus of posterior commissure	+	o	++^b
RPF	(7)(a)–(c)	Retroparafascicular nucleus	o	+	++^b
PAG	(7)(a)–(c)	Periaqueductal gray	+++^d	++^b	+++++^d
IMD	(6)(a)–(c)	Intermed-dorsal thalamic nucleus	+++^d	++^b	+++++^d
BMA	(6)(a)–(c)	Basomedial amygdaloid nucleus, anterior	+	++^b	+++^c

o: absent immunoreactivity; +: low immunoreactivity; ++: modest immunoreactivity; +++: moderate immunoreactivity; ++++: dense immunoreactivity; +++++: very dense immunoreactivity. a: punctate immunoreactivity; b: sparse immunoreactivity; c: variable density; d: cluster of dense immunoreactivity.