Review Article

Ghrelin and Functional Dyspepsia

Table 1

Diagnostic criteria and classification of FD in Rome II.

Diagnostic criteria

At least 12 weeks, which need not be consecutive, in the preceding 12 months of
 (1) Persistent or recurrent symptoms (pain or discomfort centered in the upper abdomen)
 (2) No evidence of organic disease (including at upper endoscopy) that is likely to explain the symptoms
 (3) No evidence that dyspepsia is exclusively relieved by defecation or associated with the onset of a change in stool frequency or stool form (i.e., not irritable bowel).

Classification

(B1a) Ulcer-like dyspepsia
 Pain centered in the upper abdomen is the predominant (most bothersome) symptom.
(B1b) Dysmotility-like dyspepsia
 An unpleasant or troublesome nonpainful sensation (discomfort) centered in the upper abdomen is the predominant symptom; this sensation may be characterized by or associated with upper abdominal fullness, early satiety, bloating, or nausea.
(B1c) Unspecified (nonspecific) dyspepsia
 Symptomatic patients whose symptoms do not fulfill the criteria for ulcer-like or dysmotility-like dyspepsia.