Review Article
Interactions of Gastrointestinal Peptides: Ghrelin and Its Anorexigenic Antagonists
Table 2
Interference between ghrelin and leptin.
| Reference | Interaction |
| Barazzoni 2003 [144] | Leptin injection reduces starvation-induced ghrelin secretion. | Toshinai 2001 [138] | Leptin administration increases ghrelin mRNA level in the stomach | Dixit 2004 [145] | Ghrelin inhibits leptin-induced cytokine expression | Nakazato 2001, Kim 2004 [21, 146] | Ghrelin reverses leptin-induced feeding reduction | Shintani 2001, Kohno 2003, Kohno 2007 [37, 39, 147] | Leptin suppresses Ghrelin-induced activation of NPY neurons within the ARC | Rosicka 2003, Park 2005 [148, 149] | Ghrelin and leptin levels are reversely correlated and depend on the BMI | Bagnasco 2002, Beretta 2002, Dube 2002, Bagnasco 2003 [150ā153] | Central transgenic leptin expression elevates serum ghrelin levels |
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