Structural and Functional Consequences Induced by Post-Translational Modifications in α-Defensins

Figure 3

Schematic structure of the dimeric form of HNP-1 interacting with the cell membrane. Arg residues that confer a positive net charge to HNP-1 (green) and that are involved to membrane interaction are highlighted in cyan and blue. Negatively charged groups of the cell membrane such as phosphatidyl glycerol or cardiolipin head groups are highlighted in red. Arg14 and Arg24 is the primary and secondary site of ADP-ribosylation, respectively. The schematic representation was made using Visual Molecular Dynamics (VMD) software; HNP-1 secondary structure was taken from PDB database (3GNY) while cell membrane model was created with VMD tool.