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International Journal of Peptides
Volume 2011 (2011), Article ID 708710, 3 pages
http://dx.doi.org/10.1155/2011/708710
Research Article

Activity of Cathelicidin Peptides against Simkania negevensis

1Section of Microbiology DESOS, Policlinico S. Orsola, University of Bologna, 40138 Bologna, Italy
2Department of Veterinary Medical Sciences, University of Bologna, 40064 Ozzano dell'Emilia, Italy
3Department of Life Sciences, University of Trieste, 34127, Trieste, Italy

Received 10 December 2010; Accepted 30 January 2011

Academic Editor: Peter Bergman

Copyright © 2011 Manuela Donati et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The in vitro activity of six cathelicidin peptides against the reference strain Z of Simkania negevensis was investigated. Five peptides—PG-1, Bac7, SMAP-29, BMAP-27, and BMAP-28—proved to be active at very low concentrations (1 to 0.1 μg/mL), while LL-37 cathelicidin was ineffective even at a concentration of 100 μg/mL. In comparison to chlamydiae, S. negevensis proved to be more susceptible to the antimicrobial peptides tested.