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International Journal of Peptides
Volume 2011 (2011), Article ID 945397, 3 pages
http://dx.doi.org/10.1155/2011/945397
Research Article

Radiolabeling of Cramoll 1,4: Evaluation of the Biodistribution

1Laboratory of Nanoradiopharmaceuticals, Academical Hospital Clementino Fraga Filho, 21941-913 Rio de Janeiro, RJ, Brazil
2Department of Morphological and Biochemical Analysis, Rural University of Pernambuco, 52171-900 Recife, PE, Brazil
3Department of Biochemistry, Federal University of Pernambuco, 52171-900 Recife, PE, Brazil
4Departamento de Radiologia, Hospital Universitário Clementino Fraga Filho Laboratório de Marcação de Células e Moléculas, Universidade Federal do Rio de Janeiro, 21941-901 Rio de Janeiro, RJ, Brazil

Received 11 November 2010; Accepted 4 April 2011

Academic Editor: Tzi-Bunb Ng

Copyright © 2011 Beatriz Ferreira de Carvalho Patricio et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cramoll 1,4 is a well-studied lectin. However, few studies about its biodistribution have been done before. In this study, we radiolabeled the cramol 1,4 with Tc-99m and analyzed the biodistribution. The results showed that the cramol has an abnormal uptake by the bowel with reflections on its clearance mechanism.