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International Journal of Peptides
Volume 2012 (2012), Article ID 186034, 5 pages
http://dx.doi.org/10.1155/2012/186034
Research Article

Synthesis of Hemopressin Peptides by Classical Solution Phase Fragment Condensation

Center for Organic and Medicinal Chemistry, Discovery Sciences Research Triangle Institute, Research Triangle Park, NC 27709-2194, USA

Received 22 August 2012; Accepted 25 October 2012

Academic Editor: Severo Salvadori

Copyright © 2012 P. Anantha Reddy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A fragment condensation solution phase assembly of the naturally occurring CB1 inverse agonist nonapeptides, Pro-Val-Asn-Phe-Lys-Phe/Leu-Leu-Ser-His-OH (hemopressins), and two other homologues: N-terminal 2-amino acid (dipeptide) extended undecapeptide, Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, and three-amino acid (tripeptide) extended dodecapeptide, Arg-Val-Asp-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH, both CB1 agonists, is reported.