Diet-Induced Obesity in Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons

Figure 1

The effect of the Western-type diet on body weight gain and adiposity in wildtype (WT) and heterozygous OE-NPY^DBH mice. Body weight gain curves (a, b), total weight gain (c, d), and fat tissue weights (e–h) were measured as described in Experiment 1 in Section 2, and presented here with females in the left panel (a, c, e, g) and males on the right (b, d, f, h). (a, c) Heterozygous female OE-NPY^DBH mice gained significantly more weight during the diet in comparison with their WT littermates. (b, d) The male mice were equally susceptible to weight gain in both genotypes. (e) Mean total WAT weights, (f) total WAT per body weight in percentages, and (g-h) different WAT subclass and BAT weights in female (e, g) and male (f, h) wildtype and OE-NPY^DBH mice. Values are expressed as means ± SEM. 𝑛=15, WT females; 𝑛=16, OE-NPY^DBH females; 𝑛=9, WT males; 𝑛=10, OE-NPY^DBH males. White squares and bars = WT; Black squares and bars = OE-NPY^DBH. ^∗𝑃<0.05 with a Student’s 𝑡-test; ^∗∗𝑃<0.01 with a Bonferroni posthoc test in repeated measures two-way ANOVA (a) or with a Student’s 𝑡-test (c–g); ^∗∗∗𝑃<0.001 with a Bonferroni posthoc test in repeated measures two-way ANOVA.

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