Diet-Induced Obesity in Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons

Figure 2

The effect of the Western-type diet on glucose homeostasis in wildtype (WT) and OE-NPY^DBH mice. Intraperitoneal glucose (a, b) and insulin (c, d) tolerance tests (GTT and ITT, resp.). Females are presented in the left panel (a, c) and males on the right (b, d). Mean ± SEM blood glucose values are shown at each studied time point in GTT (baseline, 20, 40, 60, and 90 min) and ITT (baseline, 20, 40, and 60 min) in female (𝑛=15, WT; 𝑛=16, OE-NPY^DBH) and male (𝑛=9, WT; 𝑛=10, OE-NPY^DBH) mice. The administration of 1.0 g kg⁻¹ glucose (a, b) and insulin 0.5 IU kg⁻¹ (c) or 1.0 IU kg⁻¹ (d) is marked at 0 min. White squares = WT; black squares = OE-NPY^DBH. ^∗𝑃<0.05 with repeated measures two-way ANOVA.

(a)

(b)

(c)

(d)