Diet-Induced Obesity in Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons

Table 1

Metabolic and endocrinological parameters in wildtype (WT) and heterozygous OE-NPY^DBH mice after seven weeks on an energy-dense Western-type diet (42% kcal fat, 43% carbohydrates, 15% protein, and 0.15% supplementary cholesterol).

	Males			Females
	WT	OE-NPY^DBH	P value	WT	OE-NPY^DBH	P value
	(𝑛=9)	(𝑛=10)		(𝑛=15)	(𝑛=16)
Plasma insulin (μg L^−1)	1.4 ± 0.19	1.8 ± 0.21	0.21	0.6 ± 0.19^a	0.5 ± 0.07^b	0.74
Plasma cholesterol (μg μL^−1)	4.3 ± 0.3	4.4 ± 0.2	0.81	1.0 ± 0.2^c	1.3 ± 0.3^b	0.32
Liver triglycerides (mg g^−1 tissue)	3.0 ± 0.3	3.1 ± 0.1	0.87	4.6 ± 0.3	4.6 ± 0.3	0.96
GTT (AUC) (mmol L^−1  × min)	1446 ± 83.0	1668 ± 113.3	0.13	961.3 ± 50.2	1115 ± 38.8	0.02

^an = 8; ^bn = 9; ^cn = 7; ND: not determined. P values were obtained with a Student’s t-test.