Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Peptide</td><td align="center">Agonist (%)   inhibition</td><td align="center">[35S]-<i>γ</i>-S-GTP incorporation% above conro</td><td align="center">% Inhibition of FSK-stimulated cAMP</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">P1*</td><td align="center">50 (3 uM)</td><td align="center">30 (1 uM)</td><td align="center">10 (10 uM)</td></tr><tr><td align="left">P12</td><td align="center">28 (30 uM)</td><td align="center">24 (30 uM)</td><td align="center">0 (30 uM)</td></tr><tr><td align="left">P13</td><td align="center">50 (15 uM)</td><td align="center">12 (30 uM)</td><td align="center">−24 (30 uM)</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

ic3 Peptide mimic coupling and signal transduction data. Summary of data generated for all ic3 experiments with P12 and P13. P1 is included as a reference, from Hayataka et al., 1998 [<a href="/journals/ijpep/2012/490734/#B49">49</a>]. Nominal values for control agonist binding were 400 fmoles/mg protein.

International Journal of Peptides

tab3

Table 3

Table 3: Intracellular Loop 2 Peptides of the Human 5HT1a Receptor are Differential Activators of Gi 