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Name | Cytogenetic location | Biologic activities |
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Transforming growth factor, beta-I; TGFB1 | 19q13.2 | Controls proliferation, differentiation, and other functions in many cell types |
Platelet-derived growth factor, alpha polypeptide; PDGFA | 7p22.3 | Potent mitogen for connective tissue cells and exerts its function by interacting with related receptor tyrosine kinases |
Platelet-derived growth factor, beta polypeptide; PDGFB | 22q13.1 | Promotes cellular proliferation and inhibits apoptosis |
Platelet-derived growth factor C; PDGFC | 4q32.1 | Increases motility in mesenchymal cells, fibroblasts, smooth muscle cells, capillary endothelial cells, and neurons |
Platelet-derived growth factor D; PDGFD | 11q22.3 | Involved in developmental and physiologic processes, as well as in cancer, fibrotic diseases, and arteriosclerosis |
Insulin-like growth factor I; IGF1 | 12q23.2 | Mediates many of the growth-promoting effects of growth hormone |
Fibroblast growth factor I; FGF1 | 5q31.3 | Induces liver gene expression, angiogenesis and fibroblast proliferation |
Epidermal growth factor; EGF | 4q25 | Induces differentiation of specific cells, is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin |
Vascular endothelial growth factor A; VEGFA | 6p21.1 | Is a mitogen primarily for vascular endothelial cells, induces angiogenesis |
Vascular endothelial growth factor B; VEGFB | 11q13.1 | Is a regulator of blood vessel physiology, with a role in endothelial targeting of lipids to peripheral tissues |
Vascular endothelial growth factor C; VEGFC | 4q34.3 | Angiogenesis and endothelial cell growth, and can also affect the permeability of blood vessels |
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