Characterization of Selective Antibacterial Peptides by Polarity Index

Table 4

SCAAP subjects identified by the polarity index method in APD Gram+/Gram− bacteria database [11] where peptides have action only on bacteria. IP: estimated isoelectric point. HM: hydrophobic moment. Status: (X) not accepted for its IP and HM parameters, because the corresponding calculations were out of the ranges [7] (see Section 2.1).

No.	Peptide	Sequence	IP	HM	Status	Reference
1	Clavanin D (sea squirt, tunicate, invertebrates, animals)	AFKLLGRIIHHVGNFVYGFSHVF	10.85	0.54		[21]
2	Palustrin-1b (frog, amphibians, animals; XXU)	ALFSILRGLKKLGNMGQAFVNCKIYKKC	10.80	0.49		[22]
3	Palustrin-1d (frog, amphibians, animals; XXU)	ALSILKGLEKLAKMGIALTNCKATKKC	10.50	0.35		[22]
4	Palustrin-1c (frog, amphibians, animals; XXU)	ALSILRGLEKLAKMGIALTNCKATKKC	10.60	0.35		[22]
5	Brevinin-1PRc (frog, amphibians, animals; XXU)	FFPMLAGVAARVVPKVICLITKKC	10.50	0.38		[23]
6	Brevinin-1Be (frog, amphibians, animals; XXU)	FLPAIVGAAAKFLPKIFCVISKKC	10.30	0.43		[24]
7	Brevinin-1HSa (frog, amphibians, animals; XXU)	FLPAVLRVAAKIVPTVFCAISKKC	10.50	0.40		[25]
8	Brevinin-1Ba (frog, amphibians, animals; XXU)	FLPFIAGMAAKFLPKIFCAISKKC	10.30	0.50		[24]
9	Brevinin-1Bc (frog, amphibians, animals; XXU)	FLPFIAGVAAKFLPKIFCAISKKC	10.30	0.49		[24]
10	RANATUERIN 4 (ranatuerin-4, frog, amphibians, animals; XXU)	FLPFIARLAAKVFPSIICSVTKKC	10.50	0.46		[26]
11	Phylloseptin-H11 (PLS-H11, Phylloseptin-13, PS-13; frog, amphibians, animals; XXA)	FLSL IPHAINAVGVHAKHF	9.65	0.36		[27]
12	Phylloseptin-H5 (phylloseptin-7, PLS-H5, PS-7, XXA, frog, amphibians, animals)	FLSLIPHAINAVSAIAKHF	9.65	0.45		[28]
13	Phylloseptin-H2 (PLS-H2, Phylloseptin-2, PS-2) (XXA, frog, amphibians, animals)	FLSLIPHAINAVSTLVHHF	7.80	0.46	X	[29]
14	Phylloseptin-B1 (PLS-B1, PBN1; frog, amphibians, animals; XXA)	FLSLIPHIVSGVAALAKHL	9.65	0.46		[30]
15	Papilosin (tunicate, ascidian, invertebrates, sea animals)	GFWKKVGSAAWGGVKAAAKGAAVGGLNALAKHIQ	11.40	0.32		[31]
16	SMAP-34 (sheep myeloid antimicrobial peptide-34; OaMAP34, ovine cathelicidin, sheep, ruminant, animals)	GLFGRLRDSLQRGGQKILEKAERIWCKIKDIFR	10.43	0.48		[32]
17	Caerin 1.17 (frog, amphibians, animals; XXA)	GLFSVLGSVAKHLLPHVAPIIAEKL	9.50	0.49		[33]
18	Caerin 1.18 (frog, amphibians, animals; XXA)	GLFSVLGSVAKHLLPHVVPVIAEKL	9.50	0.50		[33]
19	Fallaxidin 3.2 (XXA, frog, amphibians, animals)	GLLDFAKHVIGIASKL	9.50	0.49		[34]
20	Fallaxidin 3.1 (XXA, frog, amphibians, animals)	GLLDLAKHVIGIASKL	9.50	0.48		[34]
21	Dahlein 5.2 (frog, amphibians, animals)	GLLGSIGNAIGAFIANKLKPK	11.10	0.52		[35]
22	Caerin 1.2 (XXA, frog, amphibians, animals)	GLLGVLGSVAKHVLPHVVPVIAEHL	7.02	0.49	X	[36]
23	Caerin 1.4 (XXA, frog, amphibians, animals)	GLLSSLSSVAKHVLPHVVPVIAEHL	7.02	0.48	X	[36]
24	Palustrin-2SIb (frog, amphibians, animals; XXU)	GLWNSIKIAGKKLFVNVLDKIRCKVAGGCKTSPDVE	10.10	0.36		[37]
25	XPF (the xenopsin precursor fragment, African clawed frog, amphibians, animals)	GWASKIGQTLGKIAKVGLKELIQPK	11.00	0.40		[38]
26	Pleurocidin (fish, animals)	GWGSFFKKAAHVGKHVGKAALTHYL	11.00	0.34		[39]
27	Cecropin (insects, invertebrates, animals)	GWLKKIGKKIERVGQNTRDATVKGLEVAQQAANVAATVR	11.30	0.36		[40]
28	Pm_mastoparan PMM (insects, invertebrates, animals; XXA; derivatives)	INWKKIASIGKEVLKAL	10.80	0.37		[41]
29	Hinnavin II (Hin II, insects, invertebrates, animals; JJsn)	KWKIFKKIEHMGQNIRDGLIKAGPAVQVVGQAATIYKG	10.12	0.45		[42]
30	Ostrich AvBD2 (Ostrich avian beta defensin 2, ostricacin-1, OSP-1, birds, animals; BBL)	LFCRKGTCHFGGCPAHLVKVGSCFGFRACCKWPWDV	8.94	0.33	X	[43]
31	Clavanin D (sea squirt, tunicate, invertebrates, animals)	LFKLLGKIIHHVGNFVHGFSHVF	10.80	0.56		[44]
32	Enterocin Q (EntQ, class 2d bacteriocins; leaderless, that is, no signal peptide, bacteria)	MNFLKNGIAKWMTGAELQAYKKKYGCLPWEKISC	10.00	0.39		[45]
33	Temporin-1Lb (Temporin 1Lb, frog, amphibians, animals)	NFLGTLINLAKKIM	10.80	0.41		[24]
34	Bovine beta-defensin 6 (bBD-6,cow, ruminant, animals)	QGVRNHVTCRIYGGFCVPIRCPGRTRQIGTCFGRPVKCCRRW	11.30	0.37		[46]
35	mBD-4 (mBD4, mouse beta-defensin 4, or Defb4, animals; 3S=S)	QIINNPITCMTNGAICWGPCPTAFRQIGNCGHFKVRCCKIR	8.91	0.33	X	[47]
36	ChBac5 (Pro-rich; Arg-rich, goat cathelicidin, ruminant, animals)	RFRPPIRRPPIRPPFNPPFRPPVRPPFRPPFRPPFRPPIGPFP	13.45	0.50		[48]
37	Cyclic dodecapeptide (OaDode, ovine cathelicidin, sheep, ruminant, animals)	RICRIIFLRVCR	12.00	0.36		[49]
38	Bactenecin (cyclic dodecapeptide, bovine cathelicidin, cow, cattle, ruminant, animals; BBMm; JJsn; derivatives: Bac2A)	RLCRIVVIRVCR	12.00	0.33		[50]
39	RL-37 (RL37, cathelicidin, Old World monkey, primates, animals)	RLGNFFRKVKEKIGGGLKKVGQKIKDFLGNLVPRTAS	11.90	0.59		[51]
40	BACTENECIN 7 (bac-7, bac 7; bac7; Pro-rich; cow cathelicidin, ruminant, animals; BBL, SeqAR, BBPP)	RRIRPRPPRLPRPRPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPLPFPRPGPRPIPRPL	13.20	0.25		[52]
41	Bac4 (Pro-rich, Arg-rich; cow cathelicidin, ruminant, animals)	RRLHPQHQRFPRERPWPKPLSLPLPRPGPRPWPKPL	12.90	0.23		[53]
42	Hyphancin IIIE (insects, invertebrates, animals)	RWKFFKKIERVGQNVRDGLIKAGPAIQVLGAAKAL	11.80	0.41		[54]
43	Cecropin B (insects, invertebrates, animals)	RWKIFKKIEKMGRNIRDGIVKAGPAIEVLGSAKAI	11.40	0.42		[55]
44	Hyphancin IIID (insects, invertebrates, animals)	RWKIFKKIERVGQNVRDGIIKAGPAIQVLGTAKAL	11.80	0.41		[54]
45	Hyphancin IIIG (insects, invertebrates, animals)	RWKVFKKIEKVGRHIRDGVIKAGPAITVVGQATAL	11.80	0.38		[54]
46	Hyphancin IIIF (insects, invertebrates, animals)	RWKVFKKIEKVGRNIRDGVIKAGPAIAVVGQAKAL	11.80	0.39		[54]
47	Phylloseptin-H4 (Phylloseptin-6, PLS-H4, PS-6, XXA, frog, amphibians, animals)	SLIPHAINAVSAIAKHF	9.65	0.47		[29]
48	Pep5 (Lantibiotic, type 1, class 1 bacteriocin, Gram-positive bacteria; XXT3; XXW3)	TAGPAIRASVKQCQKTLKATRLFTVSCKGKNGCK	11.10	0.27		[56]
49	Clavanin C (sea squirt, tunicate, invertebrates, animals)	VFHLLGKIIHHVGNFVYGFSHVF	9.55	0.47		[21]
50	Andropin (insects, invertebrates, animals)	VFIDILDKVENAIHNAAQVGIGFAKPFEKLINPK	7.50	0.45	X	[57]
51	Clavanin A (urochordates, sea squirts, and sea pork, tunicate, invertebrates, animals)	VFQFLGKIIHHVGNFVHGFSHVF	9.71	0.61		[21]