Identification of Histoplasma-Specific Peptides in Human Urine

Table 1

Histoplasma-specific peptides identified from infected patient urine.

NCBI	Protein	Peptide	BLAST	ind.
accession	description	sequence	E-value	obs.^†
154275270	polyubiquitin	LDVESADTIDAVK	0.006	5
		TLSDYNIQKESTLHLVLR	3e−08	4
		MQIFVK	1107	4
		IQDKEGIPPDQQRLIFAGK	2e−09	3
225554709	leucyl-tRNA synthetase	IDLLAVDK	141	4
		TVPSIFSSPWPDPLLSSR	2e−08	3
		NSSTISSPPR	3.8	3
240281880	conserved hypothetical protein	NPKSRPQHLQTATTNGR	4e−07	3
		SLEILRQR	78	3
240277865	DUF500 and SH3 domain-containing protein	NAEAAGAASTKGVAGVFSYSK	3e−09	3
		IGDRTGIFPSNYVDASNL	3e−08	3
240280678	5-oxoprolinase	GITGEYIHILVKPDMEK	5e−08	3
150412285	mannosyl-oligosaccharide 1,2-alpha- mannosidase	NHTSISVQDRDPPIR	9e−06	3
150408441	ADP-ribosylation factor	ITHSWVLQSLTRRAW	2e−06	3
239613150	predicted protein	KQTNYVSGLFRNSRT	2e−05	3
240276397	histone transcription regulator slm9	AISDLSWSPDGK	0.019	3
		SWSPDG	2675	3
150406597	hypothetical protein HCAG_00002	GWDQTGSNGANL	0.019	3
240273359	glycogen debranching enzyme	RLGLSALIRE	3.8	3
150408639	predicted protein	NLLTCMSR	24	3
240274939	ubiquitin-activating enzyme	NSFVNLALPFFSFIDPIASPMDK	1e−13	2
		LNNSEPR	535	3
240281152	conserved hypothetical protein	RQFVDSLSEGLGEQGKG	2e−06	3
239614048	TdiA	RGEHKYDPVVTLQPFGNKA	2e−9	2
240273135	xaa-proaminopeptidase	SKHQHFVGLSFDTISST	5e−07	2
		DIEFLIPIQCSILSERR	5e−08	2
		LDALRVPLTHLLAVR	5e−05	2
240276009	priB	RSKERSWLMLFVYDRS	1e−07	2
150411212	methionine sulfoxide reductase msrB	YFDSIPGAVTRKEDR	1e−05	2
239611175	predicted protein	TVIVITRRSLEPAR	3e−04	2
225555719	SAM and PH domain-containing protein	NWMRELMLARALK	1e−04	2
348156	YPS-3 yeast phase-specific protein	PAPFCGTCNPISGK	1e−04	2
150409767	predicted protein	KLDGAVPFKVQTRM	1e−04	2
239609148	phenol monooxygenase	MKPFTEEETIK	0.026	2
150407363	predicted protein	KCPTLSPENKN	0.084	2
154280483	predicted protein	LLFVGSNSAPGR	0.084	2
		TLPDDHILQEAK	0.011	2
150411980	conserved hypothetical protein	KLNMRVARWRE	0.011	2
225561657	conserved hypothetical protein	ISITDPANDR	1.2	2
239613737	cysteine synthase B	RVATSILRA	36	2
240275767	conserved hypothetical protein	LSIQATLIR	20	2
		LSIQA	75910	2
240276203	DNA binding protein URE-B1	AENTAESPESEDVKVK	9e−06	1
		ADPFATTPSKPR0	0.026	1
150414072	predicted protein	MFYFDSEFVGPPR	1e−04	1
		LLWGGAQQER	0.66	1
150412949	conserved hypothetical protein	RFSIKSCLFPHAKK	1e−04	1
150412547	predicted protein	RFLQPGDLVVLKS	0.003	1
150413459	predicted protein	KLSTLVGALATRN	0.019	1
240274117	pre-mRNA splicing factor	RVAEEMRCKV	0.27	1
154282923	2-isopropylmalate synthase	ACTLAAEPDR	1.6	1
239610650	glycerol:H+ symporter	KAVLASEPRT	5.2	1

^†Number of times peptide(s) identified in independent experiments.