Proline Rich Motifs as Drug Targets in Immune Mediated Disorders
Figure 1
(a) represents the solution structure of the CD152:CD80 complex (PDB1I8 L), and (b) represents the complex of ICOS:ICOS L. Homology modeling of ICOS and ICOSL was predicted using the structures of CD152 (PDB 1AH1 and PDB 1DQT), CD80 (PDB 1DR9) respectively, as templates by Geno 3D [89] and SWISS MODEL [90]. Prediction of the structural complex was performed by ClusPro [91], the complex with least energy is shown.
