Review Article
Proline Rich Motifs as Drug Targets in Immune Mediated Disorders
Table 1
The dihedral angles of the proline-rich motifs in selected immune-response-related proteins.
| Class | | | Motif | Critical proline |
|
Cell surface proteins | CD152 | | | Phi | Psi | Mouse | 1DQT | MYPPPY | −84 | 167 | Human | 1I8L | MYPPPY | −76 | 164.6 | CD28 | | | | | Mouse | Model | MYPPPY | −53.4 | 166.5 | Human | | MYPPPY | −55.4 | 165.3 | ICOS | | | | | Mouse | Model | FDPPP | −53.4 | 167.4 | Human | | FDPPP | −83.9 | 124.2 |
|
Cytoskeletal proteins | WIP | 2IFS | LPPP | −65.9 | 157.3 | | 1MKE | LPPP | −75 | 158.1 |
|
Transcriptional factors | GILZ | | | | | Human | Molecular Model | PEAP | −67.5 | 142.5 | Mouse | | PEAP | −72.5 | 162.3 | SMRT | | | | | Human | 2ODD | PPP | −70 | 158.4 |
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