Pyrazinamide Effects on Cartilage Type II Collagen Amino Acid Composition

Table 1

Male rats cartilage type II collagen amino acid contents in control and with pyrazinamide administration at doses 1000 mg/kg and 2000 mg/kg of body weight (M ± m, 𝑛=5, residues/1000 residues).

Amino acid	Control (norm)	Pyrazinamide 1000 mg/kg	Pyrazinamide 2000 mg/kg
Hydroxylysine	5.60±1.20	4.20±0.80	3.50±0.40
Lysine	29.9±1.80	31.80±2.70	33.30±2.50
Histidine	8.30±1.20	7.10±1.30	5.60±0.30
Arginine	53.83±3.35	53.00±5.80	39.90±3.00^*#
Hydroxyproline	95.80±2.70	91.70±4.70	85.90±2.90
Aspartic acid	53.50±5.10	62.30±6.40	72.10±10.60
Threonine	29.80±6.60	29.20±1.30	33.70±2.10
Serine	34.00±1.98	49.80±1.60^∗	56.30±2.30^*#
Glutamic acid	88.10±3.47	115.40±6.30^∗	110.80±12.20^∗
Proline	91.70±1.60	91.20±4.10	86.10±3.70
Glycine	310.20±7.70	282.10±9.90	294.00±6.40
Alanine	105.62±2.78	92.60±1.80^∗	72.10±5.50^*#
Valine	24.80±1.89	16.70±3.60^∗	32.90±1.57^*#
Methionine	7.60±1.50	3.80±1.00	2.70±0.70
Isoleucine	13.35±0.79	8.30±0.80 *	10.60±1.80
Leucine	23.43±1.85	34.30±2.00 *	32.90±1.00^∗
Tyrosine	7.30±0.80	6.80±0.30	7.50±0.50
Phenylalanine	18.80±0.80	20.80±2.30	20.60±2.10

M ± m: mean ± mean standard error.
* 𝑃<0.05 statistically significant in comparison with control.
^#𝑃<0.05 statistically significant pyrazinamide, 1000 mg/kg group versus pyrazinamide, 2000 mg/kg group.