Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro
Figure 3
Amyloid beta peptides differentially inhibit DHPG-induced hippocampal theta oscillatory activity. (a) Representative recordings (left) and their corresponding power spectra (right) of hippocampal population activity recorded in control conditions (upper trace and power spectrum), after bath application of DHPG 10 µM (middle trace and power spectrum) and after the application of MPEP 25 µM (lower trace and power spectrum). The graph on the right shows the quantification of the integrated spectral power from 2 to 10 Hz. Note that DHPG induces MPEP-sensitive rhythmic oscillations that increase the power of the hippocampal population activity. (b) Representative recordings (left) and the corresponding power spectra (right) of hippocampal population activity recorded in the presence of DHPG 10 µM (upper trace and power spectrum) and after bath application of 1 µM (lower trace and power spectrum). The graph on the right shows the quantification of the integrated spectral power from 2 to 10 Hz. Note that does not affect DHPG-induced oscillatory activity. (c) Representative recordings (left) and the corresponding power spectra (right) of hippocampal population activity recorded in the presence of DHPG 10 µM (upper trace and power spectrum) and after bath application of 0.5 µM (lower trace and power spectrum). The inset shown on each power spectrum is an autocorrelogram obtained from the corresponding trace. The graph on the right shows the quantification of the integrated spectral power from 2 to 10 Hz. Note that inhibits DHPG-induced rhythmic theta oscillations. *indicates a significant difference with respect to control (), and #indicates a significant difference with respect to the DHPG-induced oscillatory activity.
