Antimicrobial Lactoferrin Peptides: The Hidden Players in the Protective Function of a Multifunctional Protein

Table 1

Amino acid sequences of LF1-11 from lactoferrin from six species.

	LF1-11	Lactoferrampin	Lactoferricin
Sequence	GRRRSVQWCAV	WNLLRQAQEKFGKDKSP	KCFQWQRNMRKVRGPPVSCIKRDS
pI	11.70	9.70	10.95
Secondary structure in the intact lactoferrin [X-ray crystallography]	Loop followed by β-strand	Amphipathic helix with a C-terminal tail	N-terminal amphipathic helix connected to a β-strand with a loop. The structural assembly is held together with a disulphide bond.
Secondary structure when isolated [NMR]	Not known	N-terminal amphipathic alpha-helical conformation across the first 11 residues and random C-terminus	N-terminal amphipathic helix and a random coil