Nociceptin Signaling Involves a Calcium-Based Depolarization in Tetrahymena thermophila
Figure 4
J-113397, a competitive inhibitor of the human nociceptin receptor, inhibits the behavioral response to 50 μM nociceptin-NH2 in Tetrahymena thermophila when applied extracellularly. The IC50 of this compound is approximately 5 μM. . represents the number of trials conducted. Each trial consisted of 10 cells, which were individually scored as positive or negative for avoidance.
