Antimicrobial Peptides: Versatile Biological Properties

Table 4

List of antimicrobial peptides with antitumour activity.

AMP	No. of amino acids	Susceptible cancer cells	References
Pardaxin	33	Murine fibrosarcoma	[91]
Dermaseptin B2	33	Prostate adenocarcinoma cell line PC3	[92]
Magainins	21 to 27	HL-60 human promyelocytic leukemia cells, human lung carcinoma cells	[93]
Gaegurins	24	HCT116 colon and MCF-7 breast carcinoma cells	[86]
Melittin	26	U937 human monocytic leukemia cells, Du145 prostate carcinoma cells, SKOV3 ovarian carcinoma cells, B16 murine melanoma cells, BEL-7402 human hepatocellular carcinoma cells	[94, 95]
LL-37		Human oral squamous carcinoma cells, KB human squamous cancer cell lines	[96]
Cecropins	24–39	HL-60 human promyelocytic leukemia cells, CCRF-SB human lymphoblastic leukemia cells, EJ human bladder carcinoma cells, ascitic colon adenocarcinoma cells, bladder tumour cells lines, RT4, 647V, J82, 486P and benign fibroblast cell line, 3T6	[97–101]
BMAP-27, BMAP-28	27, 28	Human leukemia cells, CEM-CCRF human T leukemia cells, U937 and K562 human leukemia cell lines	[102]
Defensins	29 to 45	Raji human B-lymphoma cells, human oral squamous carcinoma cells, MOT mouse teratocarcinoma cells, fibroblast and epithelial cells	[103, 104]
Lactoferricin (Lfcin B)	25	Human leukemia and breast carcinoma cells, human endothelial cells	[105, 106]
Tachyplesin I	17	Human TSU prostate carcinoma cells, endothelial cells, B16 melanoma cells, SMMC-7721 human hepatoma cells, BGC-83 human gastric adenocarcinoma cells.	[107]
PR-39	39	Human hepatocellular carcinoma cell lines	[108]
Cecropin-Melittin (CA-ME)	20	Human small cell lung cancer cell line	[109]
Cecropin-Magainin (CA-MA)	20	Jurkat T leukemia cells, K562 chronic myeloid leukemia cells	[55]