Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans

Table 1

Total amount of substance-P-, CGRP-, and VIP-IS released in plasma after the administration of Ninjinto (6.0 g) to 5 healthy volunteers with or without pirenzepine (75 mg) treatment.

	Plasma AUC0→240 min (pg mL/min)
	Ninjinto (6.0 g)	Ninjinto (6.0 g) + pirenzepine (75 mg)	Placebo
CGRP	7937.7±2485.9 *	7497.7±2465.2	5187.0±964.9
Substance P	9815.0±2182.7	4313.2±1226.4^†	5104.5±1091.1
Motilin	28360.0±3017.4	11997.4±2483.2^**†	20481.0±5693.6
Somatostatin	2870.0±512.1 *	3016.2±462.1 **	1928.7±122.9
VIP	2005.9±793.4	2004.2±915.1	2011.2±298.7

Each value represents the mean ± s.d. 𝑛=5. AUC0→240 min, area under the plasma concentration-time curve from 0 to 240 min. *𝑃<0.05 and **𝑃<0.01 significantly different compared with placebo. ^†𝑃<0.05 significantly different compared with Ninjinto alone.