Interaction between Pirenzepine and Ninjinto, a Traditional Japanese Herbal Medicine, on the Plasma Gut-Regulated Peptide Levels in Humans

Table 2

Total amount of CGRP-, substance-P-, motilin-, somatostatin-, and VIP-IS released in plasma after the administration of pirenzepine (75 mg) to 5 healthy volunteers.

	Plasma AUC0→240 min (pg mL/min)
	Pirenzepine (75 mg)	Placebo
CGRP	8864.9±1581.8 **	6306.6±542.0
Substance P	2979.4±1350.0	5104.5±1091.1
Motilin	14010.7±9483.4	20481.0±5693.6
Somatostatin	4779.3±858.5 *	3483.8±345.7
VIP	1645.6±551.5	2011.2±298.7

Each value represents the mean ± s.d. 𝑛=5. AUC0→240 min, area under the plasma concentration-time curve from 0 to 240 min. *𝑃<0.05 and **𝑃<0.01 significantly different compared with placebo.