Research Article

Urine Glycoprotein Profile Reveals Novel Markers for Chronic Kidney Disease

Table 3

Glycoproteins identified with peptides carrying NxS/T motif.

No.ProteinCharge statePeptide sequence with NxS/T motif

1155 kDa platelet multimerin (MMRN1)2+
2+
LQN[115]LTLPTN[115]ASIK
FNPGAESVVLSN[115]STLK

270 kDa lysosomal alpha-glucosidase (GAA)2+
2+
GVFITN[115]ETGQPLIGK
LEN[115]LSSSEM[147]GYTATLTR

3Afamin (AFAM)2+
2+/3+
DIENFN[115]STQK
YAEDKFN[115]ETTEK

4Aminopeptidase N (AMPN)3+
2+
KLN[115]YTLSQGHR
N[115]ATLVNEADKLR

5Attractin (ATRN)2+IDSTGN[115]VTNELR

6Apolipoprotein D
(APO D)
2+/3+
2+
ADGTVNQIEGEATPVN[115]LTEPAK
C[160]IQAN[115]YSLM[147]EN[115]GK

7Apolipoprotein F (APO F)2+Q[111]GGVN[115]ATQVLIQHLR

8Apolipoprotein J (APO J)2+
2+/3+
3+
3+
LAN[115]LTQGEDQYYLR
EDALN[115]ETRESETK
M[147]LN[115]TSSLLEQLNEQFNWVSR
EIRHN[115]STGC160LR

9Alpha-1-antichymotrypsin (AACT)3+/4+
3+/4+
2+/3+
2+/3+
GLKFN[115]LTETSEAEIHQSFQHLLR
YTGN[115]ASALFILPDQDKM[147]EEVEAM[147]LLPETLKR
TLN[115]QSSDELQLSM[147]GNAM[147]FVK
KLIN[115]DYVKN[115]GTR

10Alpha-2-HS-glycoprotein (FETUA)2+/3+
2+/3+
AALAAFNAQNN[115]GSNFQLEEISR
KVC[160]QDC[160]PLLAPLN[115]DTR

11Alpha-1-acid
glycoprotein 1 (ORM1)
2+/3+
3+
3+/4+
QDQC[160]IYN[115]TTYLNVQR
SVQEIQATFFYFTPN[115]KTEDTIFLR
N[115]EEYN[115]KSVQEIQATFFYFTPN[115]KTEDTIFLR

12Alpha-1-acid
glycoprotein 2 (ORM2)
2+/3+
3+
QNQC[160]FYN[115]SSYLNVQR
SVQEIQATFFYFTPN[115]KTEDTIFLR

13Alpha-1B-glycoprotein (A1BG)3+/4+EGDHEFLEVPEAQEDVEATFPVHQPGN[115]YSC[160]SYR

14Antithrombin-III (SERPINC1)2+/3+
2+
LGAC[160]N[115]DTLQQLM[147]EVFKFDTISEK
SLTFN[115]ETYQDISELVYGAK

15Basigin (BSG)3+
3+
ITDSEDKALM[147]N[115]GSESR
ILLTC[160]SLN[115]DSATEVTGHR

16Beta-galactosidase (GLB1)2+NNVITLN[115]ITGK

17Beta-sarcoglycan (SGCB)2+ITSN[115]ATSDLNIK

18Biotinidase (BTD)2+/3+
2+/3+
NPVGLIGAEN[115]ATGETDPSHSK
DVQIIVFPEDGIHGFN[115]FTR

19Butyrophilin,
subfamily 2, member A1 (BTN2A1)
2+GSVALVIHN[115]ITAQEN[115]GTYR

20Cathepsin D heavy chain (CTSD)2+GSLSYLN[115]VTR

21Cathepsin L (CTSL)3+YSVAN[115]DTGFVDIPKQEK

22Carboxypeptidase
B2 (CBPB2)
2+/3+QVHFFVN[115]ASDVDNVK

23Carboxypeptidase
M (CBPM)
2+
4+
NFPDAFEYNN[115]VSR
TVAQN[115]YSSVTHLHSIGK

24Calcium binding protein 39 (CAB39)2+HN[115]FTIM[147]TK

25CD276 antigen (CD276)2+VVLGAN[115]GTYSC[160]LVR

26CD163 antigen (CD163)2+APGWAN[115]SSAGSGR

27CD44 protein (CD44)2+AFN[115]STLPTM[147]AQM[147]EK

28CD7 antigen (CD7)3+GRIDFSGSQDN[115]LTITM[147]HR

29Cell adhesion molecule 1 (CADM1)2+
2+
VSLTN[115]VSISDEGR
FQLLN[115]FSSSELK

30Ceruloplasmin (CP)2+/3+
3+/4+
2+
EHEGAIYPDN[115]TTDFQR
ELHHLQEQN[115]VSNAFLDKGEFYIGSK
EN[115]LTAPGSDSAVFFEQGTTR

31Complement component C4B (C4B)2+GLN[115]VTLSSTGR

32Complement factor H (CFH)3+IPC[160]SQPPQIEHGTIN[115]SSR

33Complement factor H-related 1 (CFHR1)2+LQNNENN[115]ISC[160]VER

34Complement
factor I (CFI)
2+FLNN[115]GTC[160]TAEGK

35Cubilin (CUBN)2+
2+
LC[160]SSVN[115]VSNEIK
AGFN[115]ASFHK

36Corticosteroid-binding globulin (SERPINA6)2+
3+
AQLLQGLGFN[115]LTER
AVLQLNEEGVDTAGSTGVTLN[115]LTSKPIILR

37Colony stimulating factor 1 (macrophage) (CSF1)2+VKNVFN[115]ETK

38Delta and notch-like epidermal growth factor-related receptor (DNER)2+LVSFEVPQN[115]TSVK

39Desmocollin-2 (DSC2)2+
2+
LKAIN[115]DTAAR
AN[115]YTILK

40Desmoglein-1 (DSC1)2+DYNTKN[115]GTIK

41Desmoglein-2 (DSG2)2+
2+
IN[115]ATDADEPNTLNSK
YVQN[115]GTYTVK

42DNA ligase 4 (LIG4)2+APN[115]LTNVNK

43Dual specificity protein phosphatase CDC14B (CDC14B)2+NHN[115]VTTIIR

44Epidermal growth factor (EGF)2+GN[115]NSHILLSALK

45Epididymis secretory sperm binding protein Li 44a (SERPINA1)2+/3+/4+
3+/4+
YLGN[115]ATAIFFLPDEGKLQHLENELTHDIITK
ADTHDEILEGLNFN[115]LTEIPEAQIHEGFQELLR

46Extracellular link domain containing 1 (XLKD1)2+/3+KANQQLN[115]FTEAK

47Fibrillin 1 (FBN1)2+TAIFAFN[115]ISHVSNK

48Fibrinopeptide A (FGA)2+M[147]DGSLNFN[115]RT

49Fibronectin type III domain-containing protein 5 (FNDC5)2+FIQEVN[115]TTTR

50Frizzled protein 4 (FRP4)2+ISM[147]C[160]QNLGYN[115]VTK

51Fibronectin 1 (FN1)3+DQC[160]IVDDITYNVN[115]DTFHK

52Folate receptor alpha (FOLR1)2+GWN[115]WTSGFNK

53Galectin-3-binding protein
(LGALS3BP)
2+
2+
2+
2+
ALGFEN[115]ATQALGR
AAIPSALDTN[115]SSK
GLN[115]LTEDTYKPR
TVIRPFYLTN[115]SSGVD

54Glutaminyl-peptide cyclotransferase (QPCT)2+/3+
3+/4+
NYHQPAILN[115]SSALR
YFQN[115]YSYGGVIQDDHIPFLR

55Golgi phosphoprotein 2 (GOLPH2)3+
1+/2+
LQQDVLQFQKN[115]QTNLER
AVLVN[115]N[115]ITTGER

56Glutamyl aminopeptidase (ENPEP)2+HTAEYAAN[115]ITK

57Haptoglobin beta
chain (HP)
2+/3+
3+/4+
2+/3+/4+
3+
VVLHPN[115]YSQVDIGLIK
MVSHHN[115]LTTGATLINEQWLLTTAK
NLFLN[115]HSEN[115]ATAKDIAPTLTLYVGKK
Q[111]LVEIEKVVLHPN[115]YSQVDIGLIK

58HEG homolog 1 (HEG1)2+SYSESSSTSSSESLN[115]SSAPR

59Hemopexin (HPX)3+/4+
2+
GHGHRN[115]GTGHGN[115]STHHGPEYM[147]R
ALPQPQN[115]VTSLLGC[160]TH

60Hepatitis B virus receptor binding protein (Q6YPX1)2+EEQYN[115]STYR

61Hepatic asialoglycoprotein receptor 1 transcript variant b (ASGR1)2+ETFSN[115]FTASTEAQVK

62Heparan sulfate proteoglycan 2 (HSPG2)2+ALVN[115]FTR

63Ig alpha-1 chain C
region (IGHA1)
3+LAGKPTHVN[115]VSVVM[147]AEVDGTC[160]Y

64Ig gamma-1 chain C region (IGHG1)2+
2+/3+
EEQYN[115]STYR
TKPREEQYN[115]STYR

65 Ig gamma-2 chain C region (IGHG2)2+
2+/3+
EEQFN[115]STFR
TKPREEQFN[115]STFR

66Ig gamma-4 chain C region (IGHG4)2+
2+/3+
EEQFN[115]STFR
TKPREEQFN[115]STFR

67Ig mu chain C
region (IGHM)
2+YKN[115]NSDISSTR

68Inducible T-cell co-stimulator ligand (ICOSLG)2+TVVTYHIPQN[115]SSLENVDSR

69Insulin-like growth factor-binding
protein 3 (IGFBP3)
2+GLC[160]VN[115]ASAVSR

70Intercellular adhesion molecule 1 (ICAM1)2
2+
LNPTVTYGN[115]DSFSAK
AN[115]LTVVLLR

71Intercellular adhesion molecule 2 (ICAM2)2+GN[115]ETLHYETFGK

72Kallikrein-1 (KLK1)4+HNLFDDEN[115]TAQFVHVSESFPHPGFN[115]M[147]SLLEN[115]HTR

73KALLIKREIN-2 (KLK2)2+N[115]KSVILLGR

74Kininogen 1 (KNG1)2+
2+
3+/4+
2+
LNAENN[115]ATFYFK
ITYSIVQTN[115]C[160]SK
HGIQYFNN[115]NTQHSSLFTLNEVKR
YNSQN[115]QSNNQFVLYR

75Leucine-rich alpha-2-glycoprotein (LRG1)2+
2+/3+
MFSQN[115]DTR
KLPPGLLAN[115]FTLLR

76Leukocyte-associated immunoglobulin-like receptor 1 (LAIR1)2+/3+STYN[115]DTEDVSQASPSESEAR

77Lumican (LUM)3+KLHINHNN[115]LTESVGPLPK

78Lysosomal acid phosphatase (ACP2)2+YEQLQN[115]ETR

79Lysosomal alpha-glucosidase (GAA)2+
2+
GVFITN[115]ETGQPLIGK
LEN[115]LSSSEM[147]GYTATLTR

80Lysosome-associated membrane glycoprotein 1 (LAMP1)2+GHTLTLN[115]FTR

81Lysosomal-associated membrane protein 2, (LAMP2)2+VASVININPN[115]TTHSTGSC[160]R

82Lymphatic vessel endothelial hyaluronic acid receptor 1 (XLKD1)2+ANQQLN[115]FTEAK

83Lysyl oxidase (LOX)3+
3+
AEN[115]QTAPGEVPALSNLRPPSR
RDPGAAVPGAAN[115]ASAQQPR

84Major prion protein (PRNP)2+Q[111]HTVTTTTKGEN[115]FTETDVK

85Membrane protein FAM174A (FAM174A)2+GSEGGN[115]GSNPVAGLETDDHGGK

86Maltase-glucoamylase (MGAM)2+
2+
ILGM[147]EEPSN[115]VTVK
VILILDPAISGN[115]ETQPYPAFTR

87Microfibril-associated glycoprotein 4 (MFAP4)2+VDLEDFEN[115]NTAYAK

88Monocyte differentiation antigen CD142+LRN[115]VSWATGR

89Mucin-6 (MUC6)2+GC[160]M[147]AN[115]VTVTR

90N-acetylglucosamine-6-
sulfatase (GNS)
2+
2+
YYN[115]YTLSIN[115]GK
TPMTN[115]SSIQFLDNAFR

91N-acylsphingosine amidohydrolase (ASAH1)2+TVLEN[115]STSYEEAK

92Neuronal pentraxin receptor (NPTXR)2+ALPGGADN[115]ASVASGAAASPGPQR

93Neuropilin and tolloid-like protein 1 (NETO1)2+HESEYN[115]TTR

94Peptidase inhibitor 16 (PI16)2+SLPNFPN[115]TSATAN[115]ATGGR

95Pigment epithelium-derived factor (SERPINF1)3+VTQN[115]LTLIEESLTSEFIHDIDR

96Plasma protease
C1 inhibitor
(SERPING1)
2+/3+
2+
3+
GVTSVSQIFHSPDLAIRDTFVN[115]ASR
VLSN[115]NSDANLELINTWVAK
VGQLQLSHN[115]LSLVILVPQNLK

97Plasma serine protease inhibitor (SERPINA5)2+VVGVPYQGN[115]ATALFILPSEGK

98Platelet-derived growth factor subunit B (PDGFB)3+LLHGDPGEEDGAELDLN[115]M[147]TR

99Polytrophin (TROPH)2+N[115]N[115]VTEDIK

100Probable G-protein coupled receptor 116 (GPR116)2+
2+
ANEQVVQSLN[115]QTYK
YEEQQLEIQN[115]SSR

101Probable serine carboxypeptidase (CPVL)2+Q[111]AIHVGN[115]QTFNDGTIVEK

102Prosaposin (PSAP)2+/3+NLEKN[115]STKQEILAALEK

103Prostaglandin D2 synthase 21 kDa (PTGDS)2+/3+
2+
SVVAPATDGGLN[115]LTSTFLR
WFSAGLASN[115]SSWLR

104Prostatic acid phosphatase (ACPP)3+FLN[115]ESYKHEQVYIR

105Proteinase-activated receptor 1 (F2R)2+ATN[115]ATLDPR

106Protein shisa-7 (SHISA7)2+LTGALTGGGGAASPGAN[115]GTR

107RING finger protein 10 (RNF10)2+N[115]ESFN[115]N[115]QSR

108Secretory component (Polymeric IG Receptor) (PIGR)3+
2+
2+
2+
AN[115]LTNFPEN[115]GTFVVNIAQLSQDDSGR
Q[111]IGLYPVLVIDSSGYVNPN[115]YTGR
VPGN[115]VTAVLGETLK
YKCGLGIN[115]SR

109Slit homolog 1 (SLIT1)2+LELN[115]GN[115]N[115]ITR

110Sushi domain-containing protein 2 (SUSD2)2+SELVN[115]ETR

111Sex hormone binding globulin (SHBG)2+LDVDQALN[115]RT

112Transferrin (TF)2+/3+
2+/3+
Q[111]QQHLFGSN[115]VTDC[160]SGNFC[160]LFR
C[160]GLVPVLAENYN[115]KSDN[115]C[160]EDTPEAGYFAVAVVK

113Thrombin heavy
chain (F2)
4+YPHKPEIN[115]STTHPGADLQENFC[160]R

114Tripeptidyl-peptidase I variant (TPP1)3+FLSSSPHLPPSSYFN[115]ASGR

115Tyrosine-protein kinase receptor UFO (AXL)2+
3+
SLHVPGLN[115]KT
N[115]GSQAFVHWQEPR

116TIMP metallopeptidase inhibitor 1 (TIMP1)2+
3+
FVGTPEVN[115]QTTLYQR
SHN[115]RSEEFLIAGK

117Thyroxine-binding globulin (SERPINA7)2+TLYETEVFSTDFSN[115]ISAAK

118Trypstatin (AMBP)2+/3+SKWN[115]ITM[147]ESYVVHTNYDEYAIFLTK

119Transmembrane protein 108 (TMEM108)4+KGAGN[115]SSRPVPPAPGGHSR

120Uromodulin
(UMOD)
2+/3+
2+
2+/3+
Q[111]DFN[115]ITDISLLEHR
FALLMTNCYATPSSN[115]ATDPLK
CNTAAPMWLN[115]GTHPSSDEGIVSR

121Vasorin (VASN)2+LHEITN[115]ETFR

122Zinc-alpha-2-glycoprotein (AZGP1)2+/3+
3+/4+
2+
DIVEYYN[115]DSN[115]GSHVLQGR
AREDIFM[147]ETLKDIVEYYN[115]DSN[115]GSHVLQGR
FGCEIENN[115]RS