Review Article

Glycoproteomics-Based Identification of Cancer Biomarkers

Table 1

List of some of the US Food and Drug Administration (FDA) approved glycoprotein cancer biomarkers. CA: cancer antigen, FDP: fibrin degradation protein, sPIgR: secreted chain of the polymeric immunoglobulin receptor.

Biomarker(a)GlycosylationSourceDisease

CA15.3YesSerumBreast
CA27-29YesSerumBreast cancer
HER2/NEUYesSerumBreast cancer
Fibrin/FDPYesUrineBladder
CEA (carcinoembryonic antigen)YesSerumColon cancer
Carcinoembryonic antigen (CEA)YesSerumColon, breast, lung, pancreatic
Epidermal growth factor receptorYesTissueColon cancer
CA19-9YesSerumGastrointestinal
KITYesTissueGastrointestinal tumor
α-fetoprotein(AFP)YesSerumHepatoma, testicular cancer
Human chorionic gonadotropin-βYesSerumTesticular cancer
ThyroglobulinYesSerumThyroid cancer
CA125YesSerumOvarian
PSA (prostate-specific antigen)YesSerumProstate