Proteomic-Based Biosignatures in Breast Cancer Classification and Prediction of Therapeutic Response

Table 4

Top 20 proteins predicting tumor response to neoadjuvant treatment in HER2-positive tumors.

Rank	Protein name	Accession no.	pCR/NR mean	Subcellular location	Function
1	Enolase 1	gi∣4503571	2.59	Cytoplasm, cell membrane	Multifunctional enzyme
2	Heterogeneous nuclear ribonucleoprotein A2/B1 isoform B1	gi∣14043072	3.51	Nucleus, cytoplasm	Pre-mRNA processing
3	Heat shock 70 kDa protein 1	gi∣75061728	0.24	Cytoplasm	Stress response
4	Vimentin	gi∣62414289	9.94	Cytosol	Class III intermediate filaments
5	Vesicle amine transport protein 1	gi∣18379349	0.50	Cytoplasmic vesicle membrane	Neurotransmitter transport
6	Coronin, actin-binding protein, 1A	gi∣5902134	2.00	Cytoplasm	Component of the cytoskeleton of highly motile cells
7	Fatty acid-binding protein 4	gi∣4557579 (+1)	0.23	Cytoplasm, nucleus	Lipid transport protein
8	Peroxiredoxin 5	gi∣15826629	0.37	Mitochondrion, cytoplasm, peroxisome	Antioxidant, oxidoreductase peroxidase
9	Heat shock 70 kDa protein 9	gi∣24234688	0.15	Mitochondrion	Control of cell proliferation and cellular aging
10	Leucine aminopeptidase 3	gi∣41393561	2.94	Cell membrane, secreted	Cell-cell signaling
11	Apolipoprotein D	gi∣619383	2.90	Secreted	Lipid metabolic process
12	L-plastin	gi∣4504965	3.14	Cytoplasm, cell membrane	Activation of T cells, intracellular protein transport
13	Anterior gradient protein 2 homolog precursor	gi∣5453541	0.11	Secreted, endoplasmic reticulum	Mucus secretion
14	Heat shock 10 kDa protein 1	gi∣4504523	0.37	Mitochondrion	Stress response
15	ATP synthase, H+ transporting, mitochondrial F1 complex	gi∣4757810	0.41	Mitochondrion	Proton-transporting ATP synthase complex assembly
16	Glutathione transferase	gi∣20664358 (+5)	3.29	Cytoplasm	Glutathione metabolic process
17	Chaperonin	gi∣31542947	0.33	Mitochondrion	Stress response
18	Complement component 3 precursor	gi∣115298678	3.00	Secreted	Activation of the complement system
19	Heterogeneous nuclear ribonucleoprotein D isoform a	gi∣14110420	2.19	Nucleus, cytoplasm	Transcription regulation
20	Malate dehydrogenase	gi∣6648067 (+1)	0.22	Cytoplasm	Tricarboxylic acid cycle