Ethanol Exposure Alters Protein Expression in a Mouse Model of Fetal Alcohol Spectrum Disorders

Figure 1

Alcohol-induced dysmorphology of embryonic development at E10.25. The alcohol-treated embryos (right side of figure) showed developmental delay and abnormalities. Examples are demonstrated in small forebrain (FB), midbrain (MB), or hindbrain (HB); abnormality of the heart (H); small eyes (black arrows) as compared with control (left). A reduced blood/vascular system with lower red coloration was apparent in the alcohol-treated embryos. A major dichotomic phenotype is embryos with neural tube closed but with delay and abnormality in development (Alcohol-NTC), and neural tube opened (Alcohol-NTO). An open neural tube is shown (red arrows) in an alcohol-treated embryo (bottom right). Scale bar: 1,000 micron.