Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
Table 1
Proteomic profile of 3 independently prepared exosomes as determined by LC MS/MS and antibody arrays.
A2M
C11orf59
COPS4
FBXW8
HNRNPA1
KRT16
MMP3
PRR4
RPS3
TGFB2
ABI3BP
C1orf78
COPS8
FEN1
HP
KRT17
MOS
PRSS23
RPS4X
TGFBI
ACAA2
C1R
CPS1
FER1L3
HPX
KRT18
MPO
PSMA1
RPS5
TGM2
ACAT2
C1S
CREG1
FGA
HRSP12
KRT19
MPZL1
PSMA2
RPSA
TGOLN2
ACLY
C20orf114
CRIPT
FGB
HSP90AA1
KRT2
MRC2
PSMA3
RRAS2
THBS1
ACSL1
C3
CRTAP
FGF16
HSP90AB1
KRT27
MSN
PSMA4
RTN4
THBS2
ACTA1
C5orf24
CSF1
FGF18
HSP90B1
KRT28
MXRA5
PSMA5
RUVBL1
THY1
ACTA2
C9orf19
CSF2
FGF19
HSPA1A
KRT3
MYADM
PSMA6
S100A11
TIMP1
ACTB
C9orf91
CSF3
FGFRL1
HSPA1L
KRT4
MYCBPAP
PSMA7
S100A13
TIMP2
ACTG2
CACNA2D1
CSPG4
FGG
HSPA5
KRT5
MYH14
PSMB1
S100A8
TIMP3
ACTN1
CACNA2D4
CST4
FLG2
HSPA6
KRT6A
MYH9
PSMB10
S100P
TKT
ACTN2
CALR
CTA-221G9.4
FLJ13197
HSPA8
KRT6B
MYL6B
PSMB2
SAA4
TLN1
ACTN3
CAND1
CTBP2
FLJ22184
HSPB1
KRT6C
MYO1C
PSMB3
SASS6
TMBIM1
ACTN4
CAP1
CTNNA1
FLJ32784
HSPD1
KRT7
NBL1
PSMB4
SCAMP3
TMED10
ACTR1A
CAPNS1
CTNNA2
FLNA
HSPG2
KRT72
NEFH
PSMB5
SCGB2A1
TMED9
ACTR2
CAPZA1
CTNNB1
FLNB
HTRA1
KRT73
NEK10
PSMB6
SCYE1
TMEM16B
ACTR3
CASP14
CTNND1
FLNC
HYI
KRT74
NID1
PSMB7
SDC1
TMEM2
ADAM10
CAT
CTSG
FLOT1
ICAM1
KRT76
NLRP8
PSMB8
SDC2
TMEM47
ADAM9
CAV1
CXCL16
FLOT2
ICAM5
KRT77
NME1
PSMB9
SDC4
TMEM51
ADAMTS12
CCDC129
CXCL2
FLT1
IDH3B
KRT78
NOMO1
PSMC5
SDCBP
TNC
AEBP1
CCDC64B
CXorf39
FN1
IFITM2
KRT79
NRAS
PSMD11
SEC14L4
TNFRSF11B
AFM
CCL2
CYBRD1
FREM3
IFNG
KRT8
NRG2
PSMD14
SEMA5A
TNFRSF12A
AGRN
CCL20
DBF4B
FST
IFRD1
KRT80
NRLN1
PSMD6
SEPT2
TNFRSF1A
AHCY
CCL28
DCD
FTL
IFT140
KRT84
NRP1
PSMD7
SEPT7
TNFSF18
AHNAK2
CCL7
DCHS2
FUCA2
IGF2R
KRT9
NT5E
PTGFRN
SERINC5
TNFSF5
AHSG
CCR4
DCLK2
GALNT5
IGFBP3
LACRT
NTF5
PTK7
SERPINA1
TPBG
AKR1B1
CCR5
DCN
GANAB
IGFBP4
LAMA4
NUSAP1
PTPRK
SERPINB3
TPI1
AKR7A2
CCT5
DCTN1
GAPDH
IGFBP6
LAMB1
OBFC1
PTRF
SERPINE1
TRAP1
ALB
CCT6A
DECR1
GAPDHS
IGFBP7
LAMC1
ODZ3
PTTG1IP
SERPINE2
TREM1
ALCAM
CD109
DEFA1
GARS
IGHA1
LAMP1
OFD1
PTX3
SERPINF1
TREML2P
ALDH2
CD151
DIP2B
GAS6
IGHA2
LAMP2
OPRM1
PXDN
SFN
TRIM40
ALDH3A2
CD248
DIRAS2
GDF1
IGHG1
LAP3
OSM
PZP
SFRP1
TRIM41
ALDH6A1
CD276
DKFZp686D0972
GDF11
IGHG2
LCN1
OTC
QPCTL
SFRP4
TSN
ALDH7A1
CD44
DKK1
GDF3
IGHG4
LCN2
OXNAD1
QSOX1
SHANK3
TSNAX
ALDH9A1
CD47
DKK3
GDF5
IGHM
LDHA
OXTR
RAB10
SLAIN1
TSPAN14
ALDOA
CD59
DMBT1
GDF8
IGJ
LDHAL6B
P4HB
RAB11B
SLC16A1
TSPAN4
ALDOB
CD63
DNASE1L1
GDF9
IGKC
LDHB
PAICS
RAB14
SLC16A3
TSPAN6
ALDOC
CD81
DNPEP
GDI1
IGKV1-5
LEPRE1
PAN3
RAB15
SLC1A4
TSPAN9
ALOX12P2
CD82
DPYS
GDI2
IGL@
LGALS1
PAPPA
RAB1A
SLC1A5
TSTA3
ANG
CD9
DPYSL2
GFRA3
IGLV4-3
LGALS3
PARP10
RAB1B
SLC22A2
TTLL3
ANGPTL2
CDC2L5
DSP
GLDC
IGSF8
LGALS3BP
PARP16
RAB2A
SLC25A10
TTN
ANPEP
CDC42
DULLARD
GLUD1
IL10
LGALS8
PARVG
RAB33B
SLC25A13
TTYH3
ANXA1
CDH13
ECM1
GNA13
IL11
LGR6
PC
RAB35
SLC2A1
TUBA1A
ANXA11
CDIPT
ED1
GNAI2
IL13
LIF
PCOLCE
RAB39B
SLC2A3
TUBA1B
ANXA2
CDK5R2
EDG2
GNAL
IL15RA
LMNA
PDCD6
RAB5A
SLC38A2
TUBA1C
ANXA2P1
CEACAM8
EDIL3
GNAS
IL17B
LOC124220
PDCD6IP
RAB5B
SLC38A3
TUBB
ANXA3
CFB
EEA1
GNAT3
IL17R
LOC283523
PDGFA
RAB5C
SLC39A14
TUBB2A
ANXA4
CFI
EEF1A1
GNB1
IL19
LOC284297
PDGFC
RAB6A
SLC3A2
TUBB2C
ANXA5
CFL1
EEF1G
GNB2
IL1F9
LOC388344
PDGFRB
RAB7A
SLC44A1
TUBB3
ANXA6
CFL2
EEF2
GNB4
IL1RAP
LOC389827
PDIA3
RAB8A
SLC44A2
TUBB6
ANXA7
CFTR
EFEMP2
GNG12
IL1RAPL1
LOC442497
PEBP1
RAB8B
SLC7A10
UBA52
AP1S1
CHMP2A
EHD1
GNPDA1
IL1RL2
LOC653269
PFAS
RAC1
SLC7A5
UBB
APEH
CHST12
EHD2
GOT2
IL22RA1
LOC727942
PFKFB3
RAC2
SMARCA4
UBE1
APOA1
CITED1
EHD4
GPC1
IL23A
LOC728320
PFN1
RAD21
SMC1A
UBE2N
APOE
CLASP2
EIF4A1
GPC5
IL3
LOC728378
PFN2
RALA
SORT1
UGP2
APP
CLDN1
EMILIN1
GPI
IL5
LOC730013
PGAM2
RAN
SPACA1
UNC13B
ARF1
CLEC11A
ENG
GPR112
IL6ST
LRP1
PGD
RAP1A
SPARC
UNC45A
ARF4
CLIC1
ENO1
GREM1
IL7
LRP6
PGK1
RAP1B
SPOCK1
VAMP3
ARF5
CLIC6
ENO2
GRM2
IL8
LRRFIP2
PGLYRP2
RAP1B
SPRY4
VANGL1
ARHGAP18
CLPX
ENO3
GRM3
INHBA
LTBP1
PIGR
RAP2C
SPTAN1
VASN
ARHGAP23
CLSTN1
ENTPD4
GRM7
INHBB
LTBP2
PIP
RARRES1
SPTBN1
VAT1
ARHGDIA
CLTA
ENTPD4;LOXL2
GSN
INSR
LTF
PKM2
RASA1
SPTBN4
VCAN
ARHGEF1
CLTC
EPB41L3
GSTM1
IQGAP1
LYAR
PLAB
RASA4
SRGN
VCL
ARL6IP5
CLTCL1
EPHA2
GSTM2
ITGA11
LYZ
PLAU
RB1CC1
SRI
VCP
ARMS2
CLU
EPO
GSTM5
ITGA2
MADH4
PLEC1
RCOR2
SRPX2
VEGFC
ARPC3
CMIP
ESM1
GSTO1
ITGA3
MAMDC2
PLEKHG3
RDH5
ST6GALNAC6
VIL1
ARPC4
CNGB1
ETFB
GSTP1
ITGA4
MAP1A
PLOD1
RFTN1
STAT1
VIL2
ARPC5
COL12A1
F2R
GTPBP2
ITGA5
MAP2K6
PLOD2
RGN
STC1
VIM
ASH1L
COL14A1
F3
GYLTL1B
ITGAL
MAP3K1
PLOD3
RHOC
STC2
VTI1A
ASL
COL18A1
F8
GZMA
ITGAV
MARCKS
PLP2
RMND5A
STOM
VTN
ATP1A1
COL1A1
FADD
H2AFV
ITGB1
MARCKSL1
PLSCR3
RNF123
STOML3
WDR49
ATP1B3
COL1A2
FAH
H2AFX
ITGB5
MAT1A
PLTP
RNF40
STX12
WDR52
ATP2B1
COL2A1
FAM108A1
HBB
ITIH2
MBD3
PLUNC
RPL10A
STX2
WNT5A
ATP2B4
COL3A1
FAM129B
HBE1
ITIH4
MCC
PNO1
RPL12
SURF4
YBX1
ATP5A1
COL4A1
FAM29A
HDAC5
ITPR2
MCM10
PODN
RPL15
SVEP1
YWHAB
ATP5B
COL4A2
FAM3B
HERC5
JUP
MDH1
POLN
RPL18
SYT1
YWHAE
ATP8B3
COL4A3
FAM64A
HGF
KIAA0146
MDH2
POSTN
RPL23
SYT9
YWHAG
ATRN
COL5A1
FAM71F1
HGFR
KIAA0256
ME1
POTE2
RPL29
TAAR2
YWHAQ
ATXN1
COL5A2
FAP
HISPPD2A
KIAA0467
MECP2
PPIA
RPL35A
TAGLN
YWHAZ
AXL
COL6A1
FASN
HIST1H2AE
KIAA1881
MFAP4
PPIB
RPLP0
TALDO1
ZBTB4
BASP1
COL6A2
FAT
HIST1H2BA
KPNB1
MFGE8
PPME1
RPS10
TAS2R60
ZNF134
BDNF
COL6A3
FAT2
HIST1H2BL
KRT1
MFSD2
PPP1CC
RPS16
TCN1
ZNF503
BGN
COL7A1
FAT4
HIST1H4H
KRT10
MIF
PRDM16
RPS18
TF
ZNF614
BHMT2
COMP
FBLN1
HIST2H2BE
KRT13
MMP1
PRDX1
RPS2
TFG
BRMS1
COPB1
FBN1
HLAA
KRT14
MMP10
PRDX6
RPS24
TFRC
BSG
COPS3
FBN2
HMGCS2
KRT15
MMP2
PRNP
RPS27A
TGFB1
Regular font: identified by LC MS/MS. Underline:
identified by antibody arrays. Bold and Underline:
identified by both LC MS/MS and antibody arrays. Bold:
identified by LC MS/MS and was found to be present in at least 50% of exosomes characterized.